ReviewGenes2018
In a quest for engineering acidophiles for biomining applications: challenges and opportunities.
Review in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Biofilm engineering through c-di-GMP tuning boosts bioleaching efficiency and arsenic tolerance inApplied and environmental microbiology · 2026Article
- Integrative Multi-Omics Identify Key Secondary Metabolites Linked to Acid Tolerance inMicroorganisms · 2025Article
- Transcriptomic Analysis of the StrainInternational journal of molecular sciences · 2025Article
- Cross-species comparison of ultramafic rock bio-accelerated weathering performance.Scientific reports · 2025Article
- Microbial diversity, metabolic properties, and biotechnological prospects of acid-sulfate soils.World journal of microbiology & biotechnology · 2025Review
- The outer membrane inApplied and environmental microbiology · 2025Article
- Direct genome-scale screening of Gluconobacter oxydans B58 for rare earth element bioleaching.Communications biology · 2025Article
- Review
- Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-Oxidizing ArchaeonInternational journal of molecular sciences · 2025Article
- Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size.ACS chemical biology · 2024Article
- Microbes of biotechnological importance in acidic saline lakes in the Yilgarn Craton, Western Australia.Frontiers in microbiology · 2024Article
- Osmotic response inFrontiers in microbiology · 2024Article
- Detection of the Microbial Composition of Some Commercial Fermented Liquid Products via Metagenomic Analysis.Foods (Basel, Switzerland) · 2023Article
- Review
- Molecular Identification and Acid Stress Response of anInternational journal of molecular sciences · 2023Article
- Advances in bioleaching of waste lithium batteries under metal ion stress.Bioresources and bioprocessing · 2023Review
- Bacterial Biosorbents, an Efficient Heavy Metals Green Clean-Up Strategy: Prospects, Challenges, and Opportunities.Microorganisms · 2022Review
- Biologically engineered microbes for bioremediation of electronic waste: Wayposts, challenges and future directions.Engineering biology · 2022Review
- Fox Cluster determinants for iron biooxidation in the extremely thermoacidophilic Sulfolobaceae.Environmental microbiology · 2022Article
- The smallest space miners: principles of space biomining.Extremophiles : life under extreme conditions · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomining with acidophilic microorganisms has been used at commercial scale for the extraction of metals from various sulfide ores. With metal demand and energy prices on the rise and the concurrent decline in quality and availability of mineral resources, there is an increasing interest in applying biomining technology, in particular for leaching metals from low grade minerals and wastes. However, bioprocessing is often hampered by the presence of inhibitory compounds that originate from complex ores. Synthetic biology could provide tools to improve the tolerance of biomining microbes to various stress factors that are present in biomining environments, which would ultimately increase bioleaching efficiency. This paper reviews the state-of-the-art tools to genetically modify acidophilic biomining microorganisms and the limitations of these tools. The first part of this review discusses resilience pathways that can be engineered in acidophiles to enhance their robustness and tolerance in harsh environments that prevail in bioleaching. The second part of the paper reviews the efforts that have been carried out towards engineering robust microorganisms and developing metabolic modelling tools. Novel synthetic biology tools have the potential to transform the biomining industry and facilitate the extraction of value from ores and wastes that cannot be processed with existing biomining microorganisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.