ArticleBioconjugate chemistry2018
Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes.
Article in Bioconjugate chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Let's Stalk about Membranes: Committor-Based Enhanced Sampling of Stalk Formation.The journal of physical chemistry letters · 2026Article
- Article
- Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-based Nanoparticles.Protein and peptide letters · 2024Review
- Dumbbells, chains, and ribbons: anisotropic self-assembly of isotropic nanoparticles.Nanoscale · 2023Article
- Nanoparticle-induced biomembrane fusion: unraveling the effect of core size on stalk formation.Nanoscale advances · 2023Article
- Characterizing the Interactions of Cell-Membrane-Disrupting Peptides with Lipid-Functionalized Single-Walled Carbon Nanotubes.ACS applied materials & interfaces · 2023Article
- Amphiphilic Gold Nanoparticles: A Biomimetic Tool to Gain Mechanistic Insights into Peptide-Lipid Interactions.Membranes · 2022Review
- Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes.Nanoscale · 2022Article
- Amphiphilic nanoparticles generate curvature in lipid membranes and shape liposome-liposome interfaces.Nanoscale · 2021Article
- Cholesterol Hinders the Passive Uptake of Amphiphilic Nanoparticles into Fluid Lipid Membranes.The journal of physical chemistry letters · 2021Article
- Non-disruptive uptake of anionic and cationic gold nanoparticles in neutral zwitterionic membranes.Scientific reports · 2021Article
- Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- One Peptide for Them All: Gold Nanoparticles of Different Sizes Are Stabilized by a Common Peptide Amphiphile.ACS nano · 2020Article
- Strong dependence of the nano-bio interactions on core morphology and layer composition of ultrasmall nanostructures.The Journal of chemical physics · 2019Article
- Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: A computational study.PloS one · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The development of synthetic nanomaterials that could embed within, penetrate, or induce fusion between membranes without permanent disruption would have great significance for biomedical applications. Here we describe structure-function relationships of highly water-soluble gold nanoparticles comprised of an ∼1.5-5 nm diameter metal core coated by an amphiphilic organic ligand shell, which exhibit membrane embedding and fusion activity mediated by the surface ligands. Using an environment-sensitive dye anchored within the ligand shell as a sensor of membrane embedding, we demonstrate that particles with core sizes of ∼2-3 nm are capable of embedding within and penetrating fluid bilayers. At the nanoscale, these particles also promote spontaneous fusion of liposomes or spontaneously embed within intact liposomal vesicles. These studies provide nanoparticle design and selection principles that could be used in drug delivery applications, as membrane stains, or for the creation of novel organic/inorganic nanomaterial self-assemblies.
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Registered trials
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