ArticleSexually transmitted diseases2018
Prevalence and Detection of Trichomonas vaginalis in HIV-Infected Pregnant Women.
Article in Sexually transmitted diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Global Prevalence of and Factors Associated with Parasitic Coinfection in People Living with Viruses: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2025Pooled it
- Molecular Diagnosis ofJournal of tropical medicine · 2026Review
- Prevalence, symptomology, and correlates of curable sexually transmitted infections among pregnant women in Eastern Cape, South Africa.International journal of STD & AIDS · 2025Article
- Diagnostic accuracy of real-time polymerase chain reaction assay for the detection ofAfrican journal of laboratory medicine · 2025Review
- Article
- PerformingSexually transmitted infections · 2024Article
- Trichomoniasis.Infectious disease clinics of North America · 2023Review
- Essential Oils and Terpenic Compounds as Potential Hits for Drugs against Amitochondriate Protists.Tropical medicine and infectious disease · 2023Review
- Detection of metronidazole resistance in Trichomonas vaginalis using uncultured vaginal swabs.Parasitology research · 2022Article
- Article
- Galectins as potential therapeutic targets in STIs in the female genital tract.Nature reviews. Urology · 2022Review
- A review onSouthern African journal of infectious diseases · 2021Review
- Sexually transmitted infections in pregnant women from sub-Saharan Africa.Southern African journal of infectious diseases · 2021Review
- PersistentInternational journal of STD & AIDS · 2020Article
- Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity.Current opinion in infectious diseases · 2020Review
- Recent advances in the epidemiology, diagnosis, and management ofF1000Research · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundTrichomonas vaginalis is a sexually transmitted infection associated with increased transmission of HIV and significant adverse birth outcomes; culture and polymerase chain reaction (PCR) are commonly used in diagnosis.
methodsConsenting HIV-infected pregnant women were recruited from clinics in South Africa and screened for T. vaginalis using PCR. Polymerase chain reaction-positive women provided an additional sample for culture. We compared T. vaginalis detection between PCR and culture, and investigated how PCR cycle threshold (Ct) values differ among culture results.
resultsA total of 359 women were enrolled and 76 (20%) tested T. vaginalis PCR positive. Cultures were obtained from 61 of the PCR-positive women, and 38 (62%) were culture positive. The median baseline Ct of the PCR-positive/culture-positive group was 22.6 versus 38.0 among those who were PCR positive/culture negative (P < 0.001). Culture-positive cases had lower Ct values (higher DNA load); a Ct value less than 30 predicted positivity with a sensitivity of 97% and a specificity of 96%.
conclusionsCulture was positive in roughly half of PCR-positive cases. The culture-negative cases had significantly higher Ct values, indicating a lower concentration of T. vaginalis DNA. A Ct value of 30 provides a reliable threshold for predicting culture positivity. The clinical significance of culture-negative infections detected by PCR is still unclear.
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