ArticleeLife2018
Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned.bioRxiv : the preprint server for biology · 2026Article
- Three types of remapping with linear decoders: A population-geometric perspective.PLoS computational biology · 2025Article
- Three types of remapping with linear decoders: a population-geometric perspective.bioRxiv : the preprint server for biology · 2025Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.eLife · 2025Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.bioRxiv : the preprint server for biology · 2024Article
- A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice.Nature biomedical engineering · 2024Article
- A consistent map in the medial entorhinal cortex supports spatial memory.Nature communications · 2024Article
- A consistent map in the medial entorhinal cortex supports spatial memory.bioRxiv : the preprint server for biology · 2023Article
- Excitatory-inhibitory recurrent dynamics produce robust visual grids and stable attractors.Cell reports · 2022Article
- Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.Scientific reports · 2022Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Article
- Self-organization of a doubly asynchronous irregular network state for spikes and bursts.PLoS computational biology · 2021Article
- Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.PLoS computational biology · 2021Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- Article
- The functional organization of excitatory synaptic input to place cells.Nature communications · 2021Article
- Article
- A Model of Spatial Cell Development in Rat Hippocampus Based on Artificial Neural Network.Journal of healthcare engineering · 2021Article
- Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Flexible Switching of Receptive Fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons in the hippocampus and adjacent brain areas show a large diversity in their tuning to location and head direction, and the underlying circuit mechanisms are not yet resolved. In particular, it is unclear why certain cell types are selective to one spatial variable, but invariant to another. For example, place cells are typically invariant to head direction. We propose that all observed spatial tuning patterns - in both their selectivity and their invariance - arise from the same mechanism: Excitatory and inhibitory synaptic plasticity driven by the spatial tuning statistics of synaptic inputs. Using simulations and a mathematical analysis, we show that combined excitatory and inhibitory plasticity can lead to localized, grid-like or invariant activity. Combinations of different input statistics along different spatial dimensions reproduce all major spatial tuning patterns observed in rodents. Our proposed model is robust to changes in parameters, develops patterns on behavioral timescales and makes distinctive experimental predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.