ArticleNeurourology and urodynamics2018
Voluntary wheel running attenuates urinary bladder hypersensitivity and dysfunction following neonatal maternal separation in female mice.
Article in Neurourology and urodynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies.Neuroscience and biobehavioral reviews · 2022Pooled it
- Potential mechanisms of exercise for relieving inflammatory pain: a literature review of animal studies.Frontiers in aging neuroscience · 2024Review
- Combined effects of physical activity and life events on depression and PTSD in Chinese students aged 16-24 years.Frontiers in public health · 2024Article
- Interstitial cystitis-an imbalance of risk and protective factors?Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Review
- Animal models of interstitial cystitis/bladder pain syndrome.Frontiers in physiology · 2023Review
- Early Life Stress AffectsInternational journal of molecular sciences · 2022Review
- Reduced Hippocampal Volume and Neurochemical Response to Adult Stress Exposure in a Female Mouse Model of Urogenital Hypersensitivity.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The Effect of Chronic Psychological Stress on Lower Urinary Tract Function: An Animal Model Perspective.Frontiers in physiology · 2022Review
- Review
- An Omega-3-rich Anti-inflammatory Diet Improved Widespread Allodynia and Worsened Metabolic Outcomes in Adult Mice Exposed to Neonatal Maternal Separation.Neuroscience · 2021Article
- Voluntary Wheel Running Partially Attenuates Early Life Stress-Induced Neuroimmune Measures in the Dura and Evoked Migraine-Like Behaviors in Female Mice.Frontiers in physiology · 2021Article
- Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice.Physiology & behavior · 2020Article
- Exercise modulates neuronal activation in the micturition circuit of chronically stressed rats: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study.Physiology & behavior · 2020Article
- Voluntary exercise improves voiding function and bladder hyperalgesia in an animal model of stress-induced visceral hypersensitivity: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study.Neurourology and urodynamics · 2020Article
- Article
- Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an α1-Adrenoceptor Blocker in the Conscious and Anesthetized State.International neurourology journal · 2019Article
- Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder.American journal of physiology. Renal physiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimsPatients with interstitial cystitis/painful bladder syndrome (IC/PBS) commonly suffer from widespread pain and mood disorder, which has been attributed to improper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Voluntary exercise has been shown to improve HPA axis function, therefore we are determining whether voluntary wheel running can attenuate urological pain and dysfunction following neonatal maternal separation (NMS) in female mice.
methodsMice underwent NMS for 3 h/day from postnatal Day 1-21, were caged with free access to running wheels at 4 weeks of age, and assessed 4 weeks later for bladder sensitivity, micturition, reward behavior, mast cell degranulation, and HPA axis-related in vitro analysis.
resultsIncreased bladder sensitivity, void frequency, and mast cell degranulation was observed in adult sedentary (-Sed) NMS mice, compared to naïve-Sed controls. Sucrose preference was increased in NMS-Sed mice and corticotropin-releasing factor receptor 1 (CRF
conclusionsVoluntary exercise normalized behavioral outcomes resulting from NMS in female mice, increased hippocampal BDNF mRNA levels, and decreased mast cell degranulation in the bladder. Together these results provide novel insight into the efficacy of voluntary exercise to attenuate comorbid outcomes resulting from exposure to early life stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.