Evidence map›Paper›PMID 29464587›Full record

Trial reportDigestive diseases and sciences2018

Comparison of the Effects of Vonoprazan and Lansoprazole for Treating Endoscopic Submucosal Dissection-Induced Artificial Ulcers.

Ai Hirai, Toshihisa Takeuchi, Yoshiaki Takahashi, Shinpei Kawaguchi, Kazuhiro Ota, Satoshi Harada, Yuichi Kojima, Kazunari Tominaga, Satoshi Tokioka, Kazuhide Higuchi

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ai HiraiSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Toshihisa TakeuchiSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan. in2097@osaka-med.ac.jp.ORCID http://orcid.org/0000-0002-1233-0977
Yoshiaki TakahashiSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Shinpei KawaguchiSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Kazuhiro OtaSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Satoshi HaradaSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Yuichi KojimaSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.
Kazunari TominagaPremier Developmental Research of Medicine, Osaka Medical Collage, Osaka, Japan.
Satoshi TokiokaDepartment of Gastroenterology, First Towakai Hospital, Osaka, Japan.
Kazuhide HiguchiSecond Department of Internal Medicine, Osaka Medical Collage, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-0801, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVonoprazan exhibits a more potent, rapid, and longer-lasting inhibitory effect on gastric acid secretion than proton pump inhibitors; however, whether it is more effective than PPI for treating endoscopic submucosal dissection (ESD)-induced artificial ulcers remains controversial.

aimThis study aimed to assess and compare the effects of vonoprazan and lansoprazole for treating ESD-induced artificial ulcers.

methodsThis prospective, randomized controlled trial enrolled 149 patients who underwent ESD for the treatment of early gastric neoplasms from April 2015 to May 2017. They were randomly treated with either 20 mg/day vonoprazan (V group) or 30 mg/day lansoprazole (L group) orally. The primary end points were the area and shrinkage ratio of the ulcers at 4 and 8 weeks post-ESD.

resultsData from 127 patients were analyzed, which showed that the 4- and 8-week healing ratios were not significantly different between the V and L groups (4 weeks, 16.3 vs. 25.8%; 8 weeks, 86.9 vs. 90.9%, respectively). Similarly, the shrinkage ratio, categorized as less than 90%, 90% or more but less than 100%, or 100% at 4 weeks and as less than 100% or 100% at 8 weeks were not statistically different between the V and L groups (4 weeks: 12, 41, 8 vs. 13, 41, 12, p = 0.7246; 8 weeks: 9, 52 vs. 9, 57, p = 0.8568). Delayed bleeding was also not significantly different between both the groups (5.4 vs. 5.3%; p = 0.9844).

conclusionsVonoprazan is as effective as lansoprazole in treating ESD-induced ulcers.

Indexed as

AdenomaAgedAged, 80 and overEndoscopic Mucosal ResectionFemaleHumansLansoprazoleMaleMiddle AgedPostoperative ComplicationsProspective StudiesProton Pump InhibitorsPyrrolesStomach NeoplasmsStomach UlcerSulfonamides1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamineLansoprazoleProton Pump InhibitorsPyrrolesSulfonamidesGastric cancerGastric ulcerPotassium-competitive acid blockerProton pump inhibitor

Identifiers

PMID29464587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.