Evidence map›Paper›PMID 29464566›Full record

ReviewSub-cellular biochemistry2018

Conformational Equilibrium of Human Platelet Integrin Investigated by Three-Dimensional Electron Cryo-Microscopy.

Dorit Hanein, Niels Volkmann

Abstract readReview
In one paragraph

Review in Sub-cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Data-driven prediction of αBiophysical journal · 2024
    Article
  4. Contributions of the individual domains of αCytoskeleton (Hoboken, N.J.) · 2024
    Article
  5. Structural analysis of receptors and actin polarity in platelet protrusions.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Article
  7. Article
  8. Review
  9. Roles of Membrane Domains in Integrin-Mediated Cell Adhesion.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dorit HaneinBioinformatics and Structural Biology Program, Sanford-Burnham-Prebys Medical Discovery Institute, San Diego, CA, USA.
Niels VolkmannBioinformatics and Structural Biology Program, Sanford-Burnham-Prebys Medical Discovery Institute, San Diego, CA, USA. niels@burnham.org.
Discovery Institute · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
Molecular mechanism of BCL2-dependent apoptosisR01CA179087 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HANEIN, DORIT, MARASSI, FRANCESCA M · 2014 to 2018
$3.6M
Structural basis of allostery and mechanical properties of F-actinR01GM115972 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ALMO, STEVEN C., HANEIN, DORIT · 2016 to 2019
$2.3M
Instrumentation Upgrade: acquisition of an intermediate voltage TEMS10OD012372 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HANEIN, DORIT · 2012 to 2012
$1.9M
NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA179087NIGMS NIH HHS R01 GM115972NIH HHS S10 OD012372
6 · The paper itself

Abstract

Integrins are bidirectional transmembrane receptors that play central roles in hemostasis and arterial thrombosis. They have been subject to structural studies for many years, in particular using X-ray crystallography, nuclear magnetic resonance spectroscopy, and two-dimensional negative stain electron microscopy. Despite considerable progress, a full consensus on the molecular mechanism of integrin activation is still lacking. Three-dimensional reconstructions of full-length human platelet integrin α

Indexed as

Cryoelectron MicroscopyImaging, Three-DimensionalAnimalsHumansLipid BilayersPlatelet Glycoprotein GPIIb-IIIa ComplexProtein Structure, QuaternaryLipid BilayersPlatelet Glycoprotein GPIIb-IIIa ComplexActivationConformationElectron cryo-microscopyImage reconstructionIntegrinMembrane bilayerNanodiscsRGD peptidesSingle-spanning transmembrane receptorsTalin head domainThree-dimensional structure

Identifiers

PMID29464566
PMCPMC6038812
OpenAlexW2791538269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.