Evidence map›Paper›PMID 29464565›Full record

ReviewSub-cellular biochemistry2018

Ryanodine Receptor Structure and Function in Health and Disease.

Gaetano Santulli, Daniel Lewis, Amedee des Georges, Andrew R Marks, Joachim Frank

Abstract readReview
In one paragraph

Review in Sub-cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 126 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Expression of the Human R163C-International journal of molecular sciences · 2026
    Article
  4. Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Structural insights into the regulation of RyR1 by S100A1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. RYR2-ryanodinopathies: from calcium overload to calcium deficiency.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Gaetano SantulliThe Wu Center for Molecular Cardiology, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA.
Daniel LewisDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Amedee des GeorgesAdvanced Science Research Center at the Graduate Center of the City University of New York, New York, NY, USA.
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Joachim FrankDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. jf2192@cumc.columbia.edu.
Columbia University · USCity University of New York · USColumbia University Irving Medical Center · US

Funding

MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5M
STRUCTURE ANALYSIS OF MACROMOLECULAR ASSEMBLIESR01GM029169 · NIGMS · WADSWORTH CENTER · PI FRANK, JOACHIM · 1985 to 2019
$6.1M
Intracellular calcium leak and muscle functionR01AR060037 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2010 to 2014
$1.7M
Targeting intracellular calcium leak as novel therapy for diabetesR00DK107895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SANTULLI, GAETANO · 2018 to 2020
$741k
NHLBI NIH HHS R01 HL061503NIAMS NIH HHS R01 AR060037NIDDK NIH HHS R00 DK107895NIGMS NIH HHS R01 GM029169
6 · The paper itself

Abstract

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca

Indexed as

Calcium SignalingDiabetes MellitusMuscular DystrophiesMutationNeurodegenerative DiseasesRyanodine Receptor Calcium Release ChannelAnimalsCalciumHumansSynaptic TransmissionCalciumRyanodine Receptor Calcium Release ChannelCalcium release channelCryo-EMEndoplasmic reticulumRyanodine receptor (RyR)Sarcoplasmic reticulum

Identifiers

PMID29464565
PMCPMC5936639
OpenAlexW2792738008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.