SynthesisWorld journal of surgery2018
Prognostic Impact of Bacterobilia on Morbidity and Postoperative Management After Pancreatoduodenectomy: A Systematic Review and Meta-analysis.
Synthesis in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Whether preoperative biliary drainage leads to better patient outcomes of pancreaticoduodenectomy: a meta-analysis and systematic review.BMC gastroenterology · 2025Pooled it
- Pooled it
- Antibiotic resistance patterns of bacterial bile cultures during pancreatic surgery-a single center analysis and systematic review.Langenbeck's archives of surgery · 2022Pooled it
- Impact of preoperative internal versus external biliary drainage on surgical and oncological outcomes after pancreaticoduodenectomy: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Article
- Discordant Perioperative Prophylaxis and Major Morbidity After Pancreatoduodenectomy in Patients Undergoing PTBD: A Culture-Based Analysis.Journal of clinical medicine · 2026Article
- Bile Bacterial Colonization Increases Risk of Postoperative Pancreatic Fistula and Worsens Overall Survival Following Pancreatoduodenectomy.Journal of clinical medicine · 2026Article
- Should Preoperative Biliary Decontamination Be Considered to Minimize Morbidity and Mortality Following Pancreatoduodenectomy?Antibiotics (Basel, Switzerland) · 2026Article
- The impact of preoperative biliary drainage on bile colonization of patients undergoing pancreaticoduodenectomy.Annals of medicine · 2025Article
- Adaptation of antibiotics and antifungal strategy to preoperative biliary drainage to improve postoperative outcomes after pancreatic head resection.World journal of surgery · 2025Article
- Impact of an enhanced anti-infection prophylaxis strategy for pancreatoduodenectomy: a single centre analysis.Langenbeck's archives of surgery · 2024Article
- Article
- The Clinical Impact of Different Types of Preoperative Biliary Intervention on Postoperative Biliary Tract Infection of Patients Undergoing Pancreaticoduodenectomy.Journal of clinical medicine · 2024Article
- Relationship between Intraoperative Bile Culture Outcomes and Subsequent Postoperative Infectious Complications: A Retrospective Cohort Study.BioMed research international · 2024Article
- Microbiota modifications in prehabilitation - the next step towards comprehensive preparation for surgery. The scoping review.Przeglad gastroenterologiczny · 2024Review
- Novel Non-duct-to-Mucosa Pancreaticojejunostomy Reconstruction After Pancreaticoduodenectomy: Focus on the Occurrence of Post-pancreatectomy Hemorrhage and Intra-abdominal Abscess.Annals of surgical oncology · 2023Article
- Microbiota in the Natural History of Pancreatic Cancer: From Predisposition to Therapy.Cancers · 2022Review
- Prevention and Treatment of Grade C Postoperative Pancreatic Fistula.Journal of clinical medicine · 2022Review
- Impact of microbiota-immunity axis in pancreatic cancer management.World journal of gastroenterology · 2022Review
- Antibiotic Prophylaxis for Hepato-Biliopancreatic Surgery-A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
- A case from the future of HPB surgical oncology: resection of biliary tract cancer after immunotherapy.Journal of surgical case reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative bile analysis during pancreatoduodenectomy (PD) is performed routinely at specialized centers worldwide. However, it remains controversial if and how intraoperative bacterobilia during PD affects morbidity and its management. The aim of the study was a systematic review and meta-analysis of intraoperative bacterobilia and its impact on patient outcome after PD.
methodsFive relevant outcomes of interest were defined, and a systematic review of the literature with meta-analysis was performed according to the PRISMA guidelines.
resultsA total of 28 studies (8523 patients) were included. The median incidence of bacterobilia was 58% (interquartile range 51-67%). The most frequently isolated bacteria were Enterococcus species (51%), Klebsiella species (28%), and Escherichia coli (27%). Preoperative biliary drainage was significantly associated with bacterobilia (86 vs. 25%; RR 3.27; 95% confidence interval (CI) 2.42-4.42; p < 0.001). The incidence of surgical site infections (SSI) was significantly increased in cases with bacterobilia (RR 2.84; 95% CI 2.17-3.73; p < 0.001). Postoperative pancreatic fistula, overall postoperative morbidity, and mortality were not significantly influenced. Identical bacteria in bile and the infectious sources were found in 48% (interquartile range 34-59%) of the cases.
conclusionsBacterobilia is detected during almost every second PD and is associated with an increased rate of SSI. The microbiome from intraoperative bile and postoperative infectious sources match in ~50% of patients, providing the option of early administration of calculated antibiotics and the determination of resistance patterns.
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