Evidence map›Paper›PMID 29464302›Full record

ArticlePsychopharmacology2018

Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats.

Charles S Bockman, Wanyun Zeng, Jamie Hall, Beth Mittelstet, Liz Schwarzkopf, Dustin J Stairs

Abstract read
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In one paragraph

Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Charles S BockmanDepartment of Pharmacology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA.
Wanyun ZengDepartment of Pharmacology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA.
Jamie HallDepartment of Psychology, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA.
Beth MittelstetDepartment of Psychology, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA.
Liz SchwarzkopfDepartment of Psychology, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA.
Dustin J StairsDepartment of Psychology, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA. DustinStairs@creighton.edu.
Creighton University · US

Funding

Creighton University LB-595Nebraska Department of Health and Human Services LB506-2011-04
6 · The paper itself

Abstract

rationaleIndividuals vary in sensitivity to the behavioral effects of nicotine, resulting in differences in vulnerability to nicotine addiction. The role of rearing environment in determining individual sensitivity to nicotine is unclear. The neuropharmacological mechanisms mediating the effect of rearing environment on the behavioral actions of nicotine are also poorly understood.

objectivesThe contribution of rearing environment in determining the sensitivity to the interoceptive effects of nicotine was determined in rats reared in isolated conditions (IC) or enriched conditions (EC). The role of dopamine receptors and α4β2*-nicotinic acetylcholine (nACh) receptors in mediating the differential effect of IC and EC on the interoceptive action of nicotine was determined.

methodsThe interoceptive action of nicotine was measured as the discriminative stimulus effect of nicotine. Mecamylamine- and eticlopride-inhibition of the nicotine stimulus were used to examine nACh and dopamine receptors, respectively. α4β2*-nACh receptor expression in the mesolimbic dopamine pathway was determined by quantitative autoradiography of [

resultsEC-reared rats are less sensitive than IC-reared rats to the discriminative stimulus effects of nicotine at all but maximally effective doses. Mecamylamine inhibited the nicotine stimulus threefold more potently in EC-reared rats (IC

conclusionsRearing environment regulates the sensitivity to the interoceptive effects of nicotine and α4β2*-nACh receptor expression in the mesolimbic dopamine pathway.

Indexed as

EnvironmentSocial IsolationAnimalsDiscrimination LearningDose-Response Relationship, DrugMaleMecamylamineNicotineNicotinic AgonistsNucleus AccumbensRatsRats, Sprague-DawleyReceptors, NicotinicVentral Tegmental AreaMecamylamineNicotineNicotinic Agonistsnicotinic receptor alpha4beta2Receptors, Nicotinic[125I]-epibatidineAutoradiographyDrug discriminationEnvironmental enrichmentNicotineNicotinic acetylcholine receptorsRearing environment

Identifiers

PMID29464302
OpenAlexW2792520194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.