Evidence map›Paper›PMID 29464271›Full record

ArticleHNO2018

[Noise-induced neurodegeneration in the central auditory pathway : An overview of experimental studies in a mouse model].

M Gröschel, A Ernst, D Basta

Abstract read
PubMed Publisher
In one paragraph

Article in HNO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M GröschelKlinik für Hals‑, Nasen‑, Ohrenheilkunde, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Deutschland. moritz.groeschel@biologie.hu-berlin.de.
A ErnstKlinik für Hals‑, Nasen‑, Ohrenheilkunde, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Deutschland.
D BastaKlinik für Hals‑, Nasen‑, Ohrenheilkunde, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Deutschland.
Unfallkrankenhaus Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound.

objectiveAre degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? MATERIALS AND

methodsDetection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure.

resultsA single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex.

conclusionNoise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information.

Indexed as

Auditory PathwaysAuditory ThresholdHearing Loss, Noise-InducedAcousticsAcoustic StimulationAnimalsHearingMiceNoiseAuditory cortexAuditory disease, centralCentral nervous systemNoise-induced hearing lossThalamus

Identifiers

PMID29464271
OpenAlexW2790062668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.