Evidence map›Paper›PMID 29464195›Full record

ArticleeNeuro

Danger Changes the Way the Mammalian Brain Stores Information About Innocuous Events: A Study of Sensory Preconditioning in Rats.

Nathan M Holmes, Mukesh Raipuria, Omar A Qureshi, Simon Killcross, Fred Westbrook

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. The Molecular Substrates of Second-Order Conditioned Fear in the Basolateral Amygdala Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  4. Review
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  11. Manipulating Memory Associations Minimizes Avoidance Behavior.Frontiers in behavioral neuroscience · 2021
    Article
  12. Higher-Order Conditioning and Dopamine: Charting a Path Forward.Frontiers in behavioral neuroscience · 2021
    Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nathan M HolmesSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Mukesh RaipuriaSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0003-1662-0100
Omar A QureshiSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Simon KillcrossSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Fred WestbrookSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0002-6880-9274
UNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amygdala is a critical substrate for learning about cues that signal danger. Less is known about its role in processing innocuous or background information. The present study addressed this question using a sensory preconditioning protocol in male rats. In each experiment, rats were exposed to pairings of two innocuous stimuli in stage 1, S2 and S1, and then to pairings of S1 and shock in stage 2. As a consequence of this training, control rats displayed defensive reactions (freezing) when tested with both S2 and S1. The freezing to S2 is a product of two associations formed in training: an S2-S1 association in stage 1 and an S1-shock association in stage 2. We examined the roles of two medial temporal lobe (MTL) structures in consolidation of the S2-S1 association: the perirhinal cortex (PRh) and basolateral complex of the amygdala (BLA). When the S2-S1 association formed in a safe context, its consolidation required neuronal activity in the PRh (but not BLA), including activation of AMPA receptors and MAPK signaling. In contrast, when the S2-S1 association formed in a dangerous context, or when the context was rendered dangerous immediately after the association had formed, its consolidation required neuronal activity in the BLA (but not PRh), including activation of AMPA receptors and MAPK signaling. These roles of the PRh and BLA show that danger changes the way the mammalian brain stores information about innocuous events. They are discussed with respect to danger-induced changes in stimulus processing.

Indexed as

AnimalsAssociation LearningBasolateral Nuclear ComplexConditioning, PsychologicalFearFreezing Reaction, CatalepticMaleMAP Kinase Signaling SystemMemory ConsolidationPerirhinal CortexRandom AllocationRats, Sprague-DawleyReceptors, AMPAReceptors, AMPAamygdalaassociative learningconsolidationdangermemorysensory preconditioning

Identifiers

PMID29464195
PMCPMC5815846
OpenAlexW2781764418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.