ArticleeNeuro
Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline-Induced Model of Essential Tremor.Brain and behavior · 2026Article
- Modulation of Lingo-1 and NMDA receptor expression by memantine and vitamin D3 co-therapy attenuates motor and non-motor symptoms in essential tremor.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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- TRPC Channels Activated by G Protein-Coupled Receptors Drive CaTranslational stroke research · 2024Article
- NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse.Cerebellum (London, England) · 2024Article
- Diverse role of NMDA receptors for dendritic integration of neural dynamics.PLoS computational biology · 2023Article
- Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model.Frontiers in cellular neuroscience · 2023Article
- NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Environmental Enrichment Improves Vestibular Oculomotor Learning in Mice.Frontiers in behavioral neuroscience · 2021Article
- Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias.International journal of molecular sciences · 2020Review
- Gastrodin Ameliorates Motor Learning Deficits Through Preserving Cerebellar Long-Term Depression Pathways in Diabetic Rats.Frontiers in neuroscience · 2019Article
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Article
- Datumetine Preferentially Upregulates N-methyl-D-aspartate Receptor Signalling Pathways in Different Brain Regions of Mice.Basic and clinical neuroscienceArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In many brain regions involved in learning NMDA receptors (NMDARs) act as coincidence detectors of pre- and postsynaptic activity, mediating Hebbian plasticity. Intriguingly, the parallel fiber (PF) to Purkinje cell (PC) input in the cerebellar cortex, which is critical for procedural learning, shows virtually no postsynaptic NMDARs. Why is this? Here, we address this question by generating and testing independent transgenic lines that overexpress NMDAR containing the type 2B subunit (NR2B) specifically in PCs. PCs of the mice that show larger NMDA-mediated currents than controls at their PF input suffer from a blockage of long-term potentiation (LTP) at their PF-PC synapses, while long-term depression (LTD) and baseline transmission are unaffected. Moreover, introducing NMDA-mediated currents affects cerebellar learning in that phase-reversal of the vestibulo-ocular reflex (VOR) is impaired. Our results suggest that under physiological circumstances PC spines lack NMDARs postsynaptically at their PF input so as to allow LTP to contribute to motor learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.