Evidence map›Paper›PMID 29464185›Full record

ArticleJournal of immunology research2017

Performance Characteristics of Different Anti-Double-Stranded DNA Antibody Assays in the Monitoring of Systemic Lupus Erythematosus.

Michael Mahler, Chelsea Bentow, Tyler O'Malley, Claudia Ibarra, John Conklin, Mary Ann R Aure, Thierry Dervieux

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael MahlerInova Diagnostics Inc., San Diego, CA, USA.ORCID 0000-0002-7919-0948
Chelsea BentowInova Diagnostics Inc., San Diego, CA, USA.ORCID 0000-0002-7836-4336
Tyler O'MalleyExagen Diagnostics, Vista, CA, USA.
Claudia IbarraExagen Diagnostics, Vista, CA, USA.
John ConklinExagen Diagnostics, Vista, CA, USA.
Mary Ann R AureInova Diagnostics Inc., San Diego, CA, USA.
Thierry DervieuxExagen Diagnostics, Vista, CA, USA.ORCID 0000-0002-3799-4438
Nova Medical (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe sought to evaluate different anti-double-stranded DNA assays for their performance characteristics in monitoring disease activity fluctuations in systemic lupus erythematosus (SLE).

methods36 active SLE patients were followed monthly. At each study visit (total

resultsAt enrollment, positivity for QUANTA Lite and high-avidity anti-dsDNA assay was both 64% and significantly lower than anti-dsDNA positivity by QUANTA Flash (83%) and CLIFT (96%). Linear mixed-effects modeling indicated that the change in clinical SELENA-SLEDAI scores was associated with the titers of all anti-dsDNA with QUANTA Flash yielding the highest marginal

conclusionThese data indicate that anti-dsDNA antibodies determined by QUANTA Flash have a value in monitoring SLE disease activity.

Indexed as

Antibodies, AntinuclearAntibody AffinityComputer SimulationDisease ProgressionDNAHumansImmunoassayLupus Erythematosus, SystemicMonitoring, PhysiologicSeverity of Illness IndexAntibodies, AntinuclearDNA

Identifiers

PMID29464185
PMCPMC5804358
OpenAlexW2776757468

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.