ReviewJournal of skin cancer2017
The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma.
Review in Journal of skin cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Performance of the Monoclonal Antibody B72.3 in Diagnosis of Malignant Carcinomatous Serous Effusions-A Systematic Review and Meta-Analysis of Diagnostic Performance.Cytopathology : official journal of the British Society for Clinical Cytology · 2025Pooled it
- Basal Cell Carcinoma of the Cloacal Aperture in a Red Kangaroo (Veterinary sciences · 2025Article
- Basaloid Cell Hyperplasia Overlying Dermatofibroma.Dermatopathology (Basel, Switzerland) · 2025Article
- Cutaneous basaloid squamous cell carcinoma in a captive blue-fronted amazon (Brazilian journal of veterinary medicine · 2025Article
- The Role of Artificial Intelligence in Early Diagnosis and Molecular Classification of Head and Neck Skin Cancers: A Multidisciplinary Approach.Diagnostics (Basel, Switzerland) · 2024Review
- Mohs micrographic surgery challenges and new technologies to optimize care of cutaneous malignancies of the ear.Archives of dermatological research · 2024Review
- Metastatic papillary thyroid carcinoma in pleural effusion: a case report and review of the literature.Journal of medical case reports · 2023Review
- Adamantinoma-like ewing sarcoma arising in the pancreatic tail: a case report of a rare entity and review of the literature.Diagnostic pathology · 2023Review
- Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature.EXCLI journal · 2023Article
- Ber-EP4 staining patterns on basal cell carcinomas.Northern clinics of Istanbul · 2023Article
- Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq.Communications biology · 2022Article
- Metastatic basal cell carcinoma of buccal mucosa: a report of a rare case.World journal of surgical oncology · 2022Article
- Genomic tumor studies aid in diagnosing metastatic basal cell carcinoma: A case series.JAAD case reports · 2021Article
- Pigmented nodule on the dorsum of the foot.JAAD case reports · 2021Article
- Cutaneous Lymphadenoma: A Case of Recurrence after Shave Excision.Case reports in dermatological medicine · 2021Article
- [Young male patient with unusual space-occupying lesion of the lower eyelid].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis.Journal of oncology · 2018Article
- Clear Cell Basal Cell Carcinoma - A Rare Variant.Indian dermatology online journalArticle
- An Unusual Case of Recurrent Cutaneous Carcinomas Over Extragenital Multicentric Pigmented Bowen's Disease.Indian dermatology online journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3-10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.