Evidence map›Paper›PMID 29464117›Full record

ArticleJournal of nutrition and metabolism2017

Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods.

Bridget M Stroup, Denise M Ney, Sangita G Murali, Frances Rohr, Sally T Gleason, Sandra C van Calcar, Harvey L Levy

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nutrition and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01428258 (Phase 2 Study of Glycomacropeptide vs. Amino Acid Diet for the Management of PKU), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01428258 nacompletednot on this map

Phase 2 Study of Glycomacropeptide vs. Amino Acid Diet for the Management of PKU

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2011 to 2016Enrolled32ConditionsPhenylketonuriaArmsGMP Diet/GMP Medical Foods, AA Diet/AA Medical Foods
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Article
  6. Current state of the treatment landscape of phenylketonuria.Orphanet journal of rare diseases · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bridget M StroupDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Denise M NeyDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-2260-5313
Sangita G MuraliDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Frances RohrBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Sally T GleasonDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Sandra C van CalcarDepartment of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Harvey L LevyBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
University of Wisconsin–Madison · USBoston Children's Hospital · USOregon Health & Science University · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
Phase 2 Study of Glycomacropeptide vs. Amino Acid Diet for the Management of PKUR01FD003711 · FDA · UNIVERSITY OF WISCONSIN-MADISON · PI LEVY, HARVEY L., NEY, DENISE M · 2011 to 2014
$1.5M
FDA HHS R01 FD003711NCATS NIH HHS UL1 TR000427NICHD NIH HHS P30 HD003352
6 · The paper itself

Abstract

backgroundNutrient status in phenylketonuria (PKU) requires surveillance due to the restrictive low-Phe diet in combination with amino acid medical foods (AA-MF) or glycomacropeptide medical foods (GMP-MF). Micronutrient profiles of medical foods are diverse, and optimal micronutrient supplementation in PKU has not been established.

methodsIn a crossover design, 30 participants with PKU were randomized to consume AA-MF and Glytactin™ GMP-MF in combination with a low-Phe diet for 3 weeks each. Fasting venipunctures, medical food logs, and 3-day food records were obtained. Metabolomic analyses were completed in plasma and urine by Metabolon, Inc.

resultsThe low-Phe diets in combination with AA-MF and GMP-MF were generally adequate based on Dietary Reference Intakes, clinical measures, and metabolomics. Without micronutrient supplementation of medical foods, >70% of participants would have inadequate intakes for 11 micronutrients. Despite micronutrient supplementation of medical foods, inadequate intakes of potassium in 93% of participants and choline in >40% and excessive intakes of sodium in >63% of participants and folic acid in >27% were observed. Sugar intake was excessive and provided 27% of energy.

conclusionsNutrient status was similar with AA-MF and Glytactin GMP-MF. More research related to micronutrient supplementation of medical foods for the management of PKU is needed.

Identifiers

PMID29464117
PMCPMC5804357
OpenAlexW2777898769

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.