Evidence map›Paper›PMID 29464090›Full record

ArticleOncotarget2018

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.

Christian Spurny, Sareetha Kailayangiri, Bianca Altvater, Silke Jamitzky, Wolfgang Hartmann, Eva Wardelmann, Andreas Ranft, Uta Dirksen, Susanne Amler, Jendrik Hardes and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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  3. The implication of serum HLA-G in angiogenesis of multiple myeloma.Molecular medicine (Cambridge, Mass.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Christian SpurnyDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Sareetha KailayangiriDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Bianca AltvaterDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Silke JamitzkyDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Wolfgang HartmannGerhard Domagk Institute of Pathology, University of Muenster, Muenster, Germany.
Eva WardelmannGerhard Domagk Institute of Pathology, University of Muenster, Muenster, Germany.
Andreas RanftDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Uta DirksenDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Susanne AmlerInstitute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
Jendrik HardesDepartment of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Maike FlueggeDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Jutta MeltzerDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Nicole FarwickDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Lea GreuneDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
Claudia RossigDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Muenster, Muenster, Germany.
University Hospital Münster · DEEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ewing sarcoma (EwS) is an aggressive mesenchymal cancer of bones or soft tissues. The mechanisms by which this cancer interacts with the host immune system to induce tolerance are not well understood. We hypothesized that the non-classical, immune-inhibitory HLA-molecule HLA-G contributes to immune escape of EwS. While HLA-G

Indexed as

cellular immunotherapyEwing sarcomaHLA-Gimmune checkpointsT cells

Identifiers

PMID29464090
PMCPMC5814230
OpenAlexW2781923253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.