Evidence map›Paper›PMID 29464021›Full record

ArticleOncotarget2018

Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction.

Hao Wang, Xiao-Meng Zhang, Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Hideyuki Kuroda, Risa Kimura, Seiichiro Mine, Ikuo Kamitsukasa, Takeshi Wada and 32 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 8 institutions in 2 countries.

Hao WangDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Xiao-Meng ZhangDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Go TomiyoshiDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Rika NakamuraDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Natsuko ShinmenDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hideyuki KurodaMedical Project Division, Research Development Center, Fujikura Kasei Co., Saitama, Japan.
Risa KimuraDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Seiichiro MineDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ikuo KamitsukasaDepartment of Neurology, Chiba Rosai Hospital, Chiba, Japan.
Takeshi WadaDepartment of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
Akiyo AotsukaDepartment of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
Yoichi YoshidaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Eiichi KobayashiDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tomoo MatsutaniDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yasuo IwadateDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kazuo SugimotoDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masahiro MoriDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Akiyuki UzawaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mayumi MutoDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Minoru TakemotoDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kazuki KobayashiDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Harukiyo KawamuraDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ryoichi IshibashiDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Koutaro YokoteDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mikiko OhnoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Po-Min ChenDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Eiichiro NishiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Koh OnoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takeshi KimuraDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshio MachidaDepartment of Neurosurgery, Chiba Cerebral and Cardiovascular Center, Chiba, Japan.
Hirotaka TakizawaPort Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, Japan.
Koichi KashiwadoDepartment of Neurology, Kashiwado Hospital, Chiba, Japan.
Hideaki ShimadaDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Masaaki ItoDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Ken-Ichiro GotoDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Katsuro IwaseDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiromi AshinoDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Akiko TairaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Emiko AritaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masaki TakiguchiDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takaki HiwasaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Chiba University · JPKyoto University · JPChiba Aoba Municipal Hospital · JPFujikura (Japan) · JPShiga University of Medical Science · JPToho University · JPChiba Cerebral and Cardiovascular Center · JPChiba Rosai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient ischemic attack (TIA) is a predictor for cerebral infarction (CI), and early diagnosis of TIA is extremely important for the prevention of CI. We set out to identify novel antibody biomarkers for TIA and CI, and detected matrix metalloproteinase 1 (MMP1), chromobox homolog 1 (CBX1), and chromobox homolog 5 (CBX5) as candidate antigens using serological identification of antigens by recombinant cDNA expression cloning (SEREX) and Western blotting to confirm the presence of serum antibodies against the antigens. Amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) revealed that serum antibody levels were significantly higher in patients with TIA or acute-phase CI (aCI) compared with healthy donors (

Indexed as

antibody biomarkeratherosclerosiscerebral infarctionGerotargetSEREXTIA

Identifiers

PMID29464021
PMCPMC5814161
OpenAlexW2780280166

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.