Evidence map›Paper›PMID 29464004›Full record

ArticleTheranostics2018

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery.

Jonathan O Martinez, Roberto Molinaro, Kelly A Hartman, Christian Boada, Roman Sukhovershin, Enrica De Rosa, Dickson Kirui, Shanrong Zhang, Michael Evangelopoulos, Angela M Carter and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
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  5. What's New in Musculoskeletal Basic Science.The Journal of bone and joint surgery. American volume · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jonathan O MartinezCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Roberto MolinaroCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Kelly A HartmanCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Christian BoadaCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Roman SukhovershinDepartment of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030 USA.
Enrica De RosaDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030 USA.
Dickson KiruiDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030 USA.
Shanrong ZhangAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.
Michael EvangelopoulosCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Angela M CarterDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
James A BibbDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
John P CookeDepartment of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030 USA.
Ennio TasciottiCenter for Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave. Houston, TX 77030 USA.
Houston Methodist · USUniversity of Alabama at Birmingham · USBrigham and Women's Hospital · USTecnológico de Monterrey · MXThe University of Texas Southwestern Medical Center · US

Funding

TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2009 to 2014
$10.8M
Exosome analysis of drug-resistant cancer cells' response to nanoparticle therapyR21CA190024 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LIU, XUEWU · 2016 to 2017
$379k
Biomimetic nanovesicles to overcome multiple physiological barriers for primary and metastatic triple negative breast cancer therapyR56CA213859 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHANG, JENNY C-N · 2017 to 2017
$300k
NCI NIH HHS R21 CA190024NCI NIH HHS R56 CA213859NCI NIH HHS U54 CA143837
6 · The paper itself

Abstract

Activation of the vascular endothelium is characterized by increased expression of vascular adhesion molecules and chemokines. This activation occurs early in the progression of several diseases and triggers the recruitment of leukocytes. Inspired by the tropism of leukocytes, we investigated leukocyte-based biomimetic nanoparticles (i.e., leukosomes) as a novel theranostic platform for inflammatory diseases.

Indexed as

AnimalsBiomimetic MaterialsDrug CarriersEndothelium, VascularFluorescent DyesGadoliniumLeukocytesMembrane ProteinsMiceNanoparticlesNeoplasmsPhospholipidsProtein BindingRhodaminesStaining and LabelingTheranostic NanomedicineDrug CarriersFluorescent DyesGadoliniumMembrane ProteinsPhospholipidsRhodaminesBiomimeticEndotheliumInflammationLeukocyteMagnetic Resonance ImagingNanoparticles

Identifiers

PMID29464004
PMCPMC5817115
OpenAlexW2793211769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.