ArticleScientific reports2018
3D printed water-soluble scaffolds for rapid production of PDMS micro-fluidic flow chambers.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
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- The Concept of the Optimal Bioscaffold: Parameters, Problems, and Their Resolution Through Additive Manufacturing.Biomedicines · 2025Review
- Influence of Surface Texture in Additively Manufactured Biocompatible Materials and Triboelectric Behavior.Materials (Basel, Switzerland) · 2025Review
- Integrated Design and Fabrication of Pneumatic Soft Robot Actuators in a Single Casting Step.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications.Pharmaceutics · 2023Review
- The Additive Manufacturing Approach to Polydimethylsiloxane (PDMS) Microfluidic Devices: Review and Future Directions.Polymers · 2023Review
- Indirect 3D Bioprinting of a Robust Trilobular Hepatic Construct with Decellularized Liver Matrix Hydrogel.Bioengineering (Basel, Switzerland) · 2022Article
- Noncovalent reversible binding-enabled facile fabrication of leak-free PDMS microfluidic devices without plasma treatment for convenient cell loading and retrieval.Bioactive materials · 2022Article
- A 3D Printer in the Lab: Not Only a Toy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Low Cost, Ease-of-Access Fabrication of Microfluidic Devices Using Wet Paper Molds.Micromachines · 2022Article
- Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin.Scientific reports · 2022Article
- Upscaling of pneumatic membrane valves for the integration of 3D cell cultures on chip.Lab on a chip · 2021Article
- Investigation of Wall Shear Stress in Cardiovascular Research and in Clinical Practice-From Bench to Bedside.International journal of molecular sciences · 2021Review
- Review
- Low-cost and open-source strategies for chemical separations.Journal of chromatography. A · 2021Review
- Biomimetic Soft Polymer Microstructures and Piezoresistive Graphene MEMS Sensors Using Sacrificial Metal 3D Printing.ACS applied materials & interfaces · 2021Article
- Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds.PloS one · 2021Article
- Fabrication of Different Microchannels by Adjusting the Extrusion Parameters for Sacrificial Molds.Micromachines · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a novel method for fabrication of three-dimensional (3D) biocompatible micro-fluidic flow chambers in polydimethylsiloxane (PDMS) by 3D-printing water-soluble polyvinyl alcohol (PVA) filaments as master scaffolds. The scaffolds are first embedded in the PDMS and later residue-free dissolved in water leaving an inscription of the scaffolds in the hardened PDMS. We demonstrate the strength of our method using a regular, cheap 3D printer, and evaluate the inscription process and the channels micro-fluidic properties using image analysis and digital holographic microscopy. Furthermore, we provide a protocol that allows for direct printing on coverslips and we show that flow chambers with a channel cross section down to 40 μm × 300 μm can be realized within 60 min. These flow channels are perfectly transparent, biocompatible and can be used for microscopic applications without further treatment. Our proposed protocols facilitate an easy, fast and adaptable production of micro-fluidic channel designs that are cost-effective, do not require specialized training and can be used for a variety of cell and bacterial assays. To help readers reproduce our micro-fluidic devices, we provide: full preparation protocols, 3D-printing CAD files for channel scaffolds and our custom-made molding device, 3D printer build-plate leveling instructions, and G-code.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.