ArticleScience signaling2018
A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.
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Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Exploring multiple drug actions of a CaNaunyn-Schmiedeberg's archives of pharmacology · 2026Review
- An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- ADAM19 cleaves the PTH receptor and associates with brachydactyly type E.Life science alliance · 2024Article
- Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.ACS pharmacology & translational science · 2022Article
- Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation.Frontiers in physiology · 2022Review
- The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Naturally Occurring Genetic Variants in the Oxytocin Receptor Alter Receptor Signaling Profiles.ACS pharmacology & translational science · 2021Article
- Calcium-Sensing Receptors Control CYP27B1-Luciferase Expression: Transcriptional and Posttranscriptional Mechanisms.Journal of the Endocrine Society · 2021Article
- Heterogeneity of G protein activation by the calcium-sensing receptor.Journal of molecular endocrinology · 2021Article
- Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.Human molecular genetics · 2021Article
- Calcium-sensing receptor signaling - How human disease informs biology.Current opinion in endocrine and metabolic research · 2021Article
- Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.Trends in biochemical sciences · 2020Review
- Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model.JBMR plus · 2020Article
- International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.Pharmacological reviews · 2020Review
- Familial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population.American journal of human genetics · 2020Article
- Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1).The Journal of clinical endocrinology and metabolism · 2020Article
- Biased Signaling and Allosteric Modulation at the FSHR.Frontiers in endocrinology · 2019Review
- The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.Nature reviews. Endocrinology · 2018Review
- Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.Human molecular genetics · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Caroline M GorvinAcademic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK.ORCID 0000-0002-1361-9174
Valerie N BabinskyAcademic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK.ORCID 0000-0002-0586-2924
Tomas MalinauskasDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-4847-5529
Peter H NissenDepartment of Clinical Biochemistry, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.ORCID 0000-0002-8201-1306
Anders J SchouHans Christian Andersen Children's Hospital, Odense University Hospital, 5000 Odense C, Denmark.ORCID 0000-0001-6761-4275
Aylin C HanyalogluInstitute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London W12 0NN, UK.ORCID 0000-0003-4206-737X
Christian SieboldDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-6635-3621
E Yvonne JonesDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-3834-1893
Fadil M HannanAcademic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK. rajesh.thakker@ndm.ox.ac.uk fadil.hannan@liverpool.ac.uk.ORCID 0000-0002-2975-5170
Rajesh V ThakkerAcademic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK. rajesh.thakker@ndm.ox.ac.uk fadil.hannan@liverpool.ac.uk.ORCID 0000-0002-1438-3220
Centre for Human Genetics · GBOxford Centre for Diabetes, Endocrinology and Metabolism · GBAarhus University Hospital · DKImperial College London · GBOdense University Hospital · DKUniversity of Liverpool · GB
Funding
Comprehensive Sequencing and Analysis of Variation in NHLBI CohortsUC2HL102925 · NHLBI · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, GABRIEL, STACEY · 2010 to 2010
$14.7MNorthwest Genomics CenterUC2HL102926 · NHLBI · UNIVERSITY OF WASHINGTON · PI GREEN, PHILIP P, NICKERSON, DEBORAH A · 2010 to 2010
$14.0MNorthwest Genomics CenterRC2HL102926 · NHLBI · UNIVERSITY OF WASHINGTON · PI GREEN, PHILIP P, NICKERSON, DEBORAH A · 2009 to 2009
$11.0MComprehensive Sequencing and Analysis of Variation in NHLBI CohortsRC2HL102925 · NHLBI · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, GABRIEL, STACEY · 2009 to 2009
$10.2MARRA - NHLBI Lung Cohorts Sequencing ProjectRC2HL102923 · NHLBI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, BARNES, KATHLEEN C · 2009 to 2009
$2.6MARRA - NHLBI Lung Cohorts Sequencing ProjectUC2HL102923 · NHLBI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, BARNES, KATHLEEN C · 2010 to 2010
$2.6MWHI Sequencing Project (WHISP)UC2HL102924 · NHLBI · OHIO STATE UNIVERSITY · PI CARLSON, CHRISTOPHER S, JACKSON, REBECCA D · 2010 to 2010
$2.4MWHI Sequencing Project (WHISP)RC2HL102924 · NHLBI · OHIO STATE UNIVERSITY · PI CARLSON, CHRISTOPHER S, JACKSON, REBECCA D · 2009 to 2009
$2.1MHuman Exome Sequencing in Six Well-Phenotyped NHLBI CohortsUC2HL103010 · NHLBI · UNIVERSITY OF VIRGINIA · PI RICH, STEPHEN S. · 2010 to 2010
$1.5MHuman Exome Sequencing in Six Well-Phenotyped NHLBI CohortsRC2HL103010 · NHLBI · UNIVERSITY OF VIRGINIA · PI RICH, STEPHEN S. · 2009 to 2009
$817kCancer Research UK 14414Cancer Research UK 26752Medical Research Council G1000467NHLBI NIH HHS RC2 HL102923NHLBI NIH HHS RC2 HL102924NHLBI NIH HHS RC2 HL102925NHLBI NIH HHS RC2 HL102926NHLBI NIH HHS RC2 HL103010NHLBI NIH HHS UC2 HL102923NHLBI NIH HHS UC2 HL102924NHLBI NIH HHS UC2 HL102925NHLBI NIH HHS UC2 HL102926NHLBI NIH HHS UC2 HL103010Wellcome Trust 106995
Abstract
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through G
Indexed as
MAP Kinase Signaling SystemMutationAmino Acid SequenceBase Sequencebeta-ArrestinsCalciumCell MembraneFamily HealthFemaleHumansHypercalciuriaHypocalcemiaHypoparathyroidismMaleModels, MolecularPedigreebeta-ArrestinsCalciumReceptors, Calcium-SensingSalts
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