ArticleProceedings of the National Academy of Sciences of the United States of America2018
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 140 citations in OpenAlex.
- Remediation of organic pollutants by Fenton-like reactions with spinel catalysts: pathways, transformation products, and reactor perspectives.Environmental science and pollution research international · 2026Review
- Mineralization of decachlorobiphenyl in concrete using alcohol washing followed by UV irradiation.Journal of hazardous materials · 2026Article
- Disinfection Byproducts Confirmed over 50 Years: Systematic Curation, Modes of Toxic Action, and Toxicogenomics.Environmental science & technology · 2025Review
- Physiological roles of lignins - tuning cell wall hygroscopy and biomechanics.The New phytologist · 2025Review
- Pathways and selectivity of Fenton degradation of different precursor species of dissolved organic matter.Nature communications · 2025Article
- Ozone Reactions with Olefins and Alkynes: Kinetics, Activation Energies, and Mechanisms.Environmental science & technology · 2025Article
- Solid-Phase Reactivity-Directed Extraction (SPREx): An Alternative Approach for Simultaneous Extraction, Identification, and Prioritization of Toxic Electrophiles Produced in Water Treatment Applications.ACS environmental Au · 2024Article
- Unveiling the environmental significance of acetylperoxyl radical: Reactivity quantification and kinetic modeling.PNAS nexus · 2024Article
- Should Transformation Products Change the Way We Manage Chemicals?Environmental science & technology · 2024Article
- Carbon redirection via tunable Fenton-like reactions under nanoconfinement toward sustainable water treatment.Nature communications · 2024Article
- Predicting Transformation Products during Aqueous Oxidation Processes: Current State and Outlook.Environmental science & technology · 2023Review
- Reactivity of Bromine Radical with Dissolved Organic Matter Moieties and Monochloramine: Effect on Bromate Formation during Ozonation.Environmental science & technology · 2023Article
- Removal and detoxification of pentahalogenated phenols using a photocatalytically induced enzymatic process.Heliyon · 2023Article
- Nanomaterials for Removal of Phenolic Derivatives from Water Systems: Progress and Future Outlooks.Molecules (Basel, Switzerland) · 2023Review
- In situ ligand-modulated activation of inert Ce(III/IV) into ozonation catalyst for efficient water treatment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview.Pharmaceutics · 2023Review
- Promising Low-Cost Adsorbent from Waste Green Tea Leaves for Phenol Removal in Aqueous Solution.International journal of environmental research and public health · 2022Article
- The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment.Archives of toxicology · 2022Review
- Reactions of α,β-Unsaturated Carbonyls with Free Chlorine, Free Bromine, and Combined Chlorine.Environmental science & technology · 2021Article
- Activated Carbon from Agricultural Wastes for Adsorption of Organic Pollutants.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Water treatment systems frequently use strong oxidants or UV light to degrade chemicals that pose human health risks. Unfortunately, these treatments can result in the unintended transformation of organic contaminants into toxic products. We report an unexpected reaction through which exposure of phenolic compounds to hydroxyl radicals (•OH) or UV light results in the formation of toxic α,β-unsaturated enedials and oxoenals. We show that these transformation products damage proteins by reacting with lysine and cysteine moieties. We demonstrate that phenolic compounds react with •OH produced by the increasingly popular UV/hydrogen peroxide (H
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.