ArticleProceedings of the National Academy of Sciences of the United States of America2018
Defining the sizes of airborne particles that mediate influenza transmission in ferrets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 90 citations in OpenAlex.
- Updated A(H1N1)pdm09 influenza virus ferret infection model permits refined antiviral assessment using aerosol inhalation challenge.PLoS pathogens · 2026Article
- Environmental temperature and relative humidity shape post-emission aerosol fate and airborne influenza transmission.Journal of virology · 2026Article
- Filamentous morphology of influenza A virus confers enhanced stability in aerosols.Nature communications · 2026Article
- Advancing A(H5N1) influenza risk assessment in ferrets through comparative evaluation of airborne virus shedding patterns.Nature communications · 2026Article
- Size distribution and viral RNA load of influenza virus-laden airborne particles emitted from pigs over the course of an H1N1 infection.Scientific reports · 2025Article
- Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals.Nature microbiology · 2025Article
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- The pathogenesis of influenza in intact alveoli: virion endocytosis and its effects on the lung's air-blood barrier.Frontiers in immunology · 2024Review
- Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets.Npj viruses · 2024Article
- At the crossroads of epidemiology and biology: Bridging the gap between SARS-CoV-2 viral strain properties and epidemic wave characteristics.Biochimie · 2023Review
- Persistence of Coronavirus on Surface Materials and Its Control Measures Using Nonthermal Plasma and Other Agents.International journal of molecular sciences · 2023Review
- Combining a parsimonious mathematical model with infection data from tailor-made experiments to understand environmental transmission.Scientific reports · 2023Article
- Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs.Science advances · 2023Article
- On the triad of air PM pollution, pathogenic bioaerosols, and lower respiratory infection.Environmental geochemistry and health · 2023Review
- Aerosolize this: Generation, collection, and analysis of aerosolized virus in laboratory settings.PLoS pathogens · 2023Article
- Kinetics and magnitude of viral RNA shedding as indicators for Influenza A virus transmissibility in ferrets.Communications biology · 2023Article
- Detection of Airborne Influenza A and SARS-CoV-2 Virus Shedding following Ocular Inoculation of Ferrets.Journal of virology · 2022Article
- The airborne contagiousness of respiratory viruses: A comparative analysis and implications for mitigation.Geoscience frontiers · 2022Article
- Risk assessment for long- and short-range airborne transmission of SARS-CoV-2, indoors and outdoors.PNAS nexus · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
Abstract
Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.