Evidence map›Paper›PMID 29463698›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structural basis and energy landscape for the Ca

Ganeko Bernardo-Seisdedos, Eider Nuñez, Carolina Gomis-Perez, Covadonga Malo, Álvaro Villarroel, Oscar Millet

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Calmodulin assists during co-translational folding of the KProtein science : a publication of the Protein Society · 2026
    Article
  2. Article
  3. Article
  4. On the Rational Design of Cooperative Receptors.Annual review of biophysics · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021
    Article
  11. Article
  12. Rational design to control the trade-off between receptor affinity and cooperativity.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
  14. Atomistic Insights of Calmodulin Gating of Complete Ion Channels.International journal of molecular sciences · 2020
    Review
  15. Article
  16. Review
  17. A mutually induced conformational fit underlies CaThe Journal of biological chemistry · 2019
    Article
  18. The Crossroad of Ion Channels and Calmodulin in Disease.International journal of molecular sciences · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ganeko Bernardo-SeisdedosProtein Stability and Inherited Disease Laboratory, Center for Cooperative Research in Biosciences CIC bioGUNE, 48170 Derio, Spain.ORCID 0000-0002-1372-3844
Eider NuñezInstituto Biofisika (Consejo Superior de Investigaciones Científicas, Universidad del País Vasco), University of Basque Country, 48940 Leioa, Spain.ORCID 0000-0001-8075-9815
Carolina Gomis-PerezInstituto Biofisika (Consejo Superior de Investigaciones Científicas, Universidad del País Vasco), University of Basque Country, 48940 Leioa, Spain.ORCID 0000-0002-6818-4403
Covadonga MaloInstituto Biofisika (Consejo Superior de Investigaciones Científicas, Universidad del País Vasco), University of Basque Country, 48940 Leioa, Spain.ORCID 0000-0002-4014-8937
Álvaro VillarroelInstituto Biofisika (Consejo Superior de Investigaciones Científicas, Universidad del País Vasco), University of Basque Country, 48940 Leioa, Spain alvaro.villarroel@csic.es omillet@cicbiogune.es.
Oscar MilletProtein Stability and Inherited Disease Laboratory, Center for Cooperative Research in Biosciences CIC bioGUNE, 48170 Derio, Spain; alvaro.villarroel@csic.es omillet@cicbiogune.es.
Consejo Superior de Investigaciones Científicas · ESCIC bioGUNE · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K

Indexed as

KCNQ2 Potassium ChannelAnimalsCalciumCalmodulinCattleHEK293 CellsHumansProtein ConformationStatic ElectricityThermodynamicsCalciumCalmodulinKCNQ2 Potassium Channelcalcium regulationcalmodulinion channelKv7 potassium channelM-current

Identifiers

PMID29463698
PMCPMC5873240
OpenAlexW2790340711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.