Evidence map›Paper›PMID 29463694›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.

Vincent van der Vinne, Steven J Swoap, Thomas J Vajtay, David R Weaver

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Cell-Type-Specific Circadian Bioluminescence Rhythms inJournal of biological rhythms · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Circadian Clocks, Sleep, and Metabolism.Advances in experimental medicine and biology · 2021
    Article
  13. Article
  14. Review
  15. Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020
    Review
  16. Article
  17. Circadian regulation of depression: A role for serotonin.Frontiers in neuroendocrinology · 2019
    Review
  18. Evidence for Internal Desynchrony Caused by Circadian Clock Resetting.The Yale journal of biology and medicine · 2019
    Review
  19. Review
  20. Clocks and meals keep mice from being cool.The Journal of experimental biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vincent van der VinneDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605; vincentvandervinne@gmail.com david.weaver@umassmed.edu.
Steven J SwoapDepartment of Biology, Williams College, Williamstown, MA 01267.
Thomas J VajtayDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605.
David R WeaverDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605; vincentvandervinne@gmail.com david.weaver@umassmed.edu.ORCID 0000-0001-7941-6719
University of Massachusetts Chan Medical School · USWilliams College · US

Funding

Mechanisms of Circadian Rhythmicity in CLOCK-Deficient MiceR01NS056125 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WEAVER, DAVID RAYMOND · 2006 to 2017
$3.6M
Consequences of Circadian DesynchronyR21ES024684 · NIEHS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WEAVER, DAVID RAYMOND · 2014 to 2015
$461k
AREA: A1 - Hypothermia vs. Daily torpor: an integrative molecular /biochemical /R15HL120072 · NHLBI · WILLIAMS COLLEGE · PI SWOAP, STEVEN JOHN · 2014 to 2014
$410k
NHLBI NIH HHS R15 HL120072NIEHS NIH HHS R21 ES024684NINDS NIH HHS R01 NS056125
6 · The paper itself

Abstract

Circadian disruption as a result of shift work is associated with adverse metabolic consequences. Internal desynchrony between the phase of the suprachiasmatic nuclei (SCN) and peripheral clocks is widely believed to be a major factor contributing to these adverse consequences, but this hypothesis has never been tested directly. A GABAergic Cre driver combined with conditional casein kinase mutations (

Indexed as

Circadian ClocksAnimalsCasein Kinase 1 epsilonCasein Kinase IdeltaCircadian RhythmFemaleGABAergic NeuronsGene Knockout TechniquesGene SilencingMaleMiceMice, Inbred C57BLSuprachiasmatic NucleusCasein Kinase 1 epsilonCasein Kinase Ideltacircadianclock genesPER2::luciferaseperipheral oscillatorsuprachiasmatic nucleus

Identifiers

PMID29463694
PMCPMC5877989
OpenAlexW2789915134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.