Evidence map›Paper›PMID 29463649›Full record

ArticleMolecular and cellular biology2018

Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor α Coactivator.

Tali Shalom-Barak, Jaclyn Liersemann, Babak Memari, Lawrence Flechner, Caitlin E Devor, Tiffany M Bernardo, Suyeon Kim, Nobuyuki Matsumoto, Scott L Friedman, Ronald M Evans and 2 more

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Tali Shalom-BarakMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jaclyn LiersemannMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Babak MemariDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
Lawrence FlechnerGene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, USA.
Caitlin E DevorMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tiffany M BernardoMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Suyeon KimMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nobuyuki MatsumotoDivision of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan.
Scott L FriedmanDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ronald M EvansGene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, USA.
John H WhiteDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
Yaacov BarakMagee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA baraky@mwri.magee.edu.ORCID 0000-0002-4362-7669
University of Pittsburgh · USMcGill University · CASalk Institute for Biological Studies · USIcahn School of Medicine at Mount Sinai · USSt. Marianna University School of Medicine · JP

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4M
HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0M
The Role of KLF6 in Hepatic FibrosisR01DK056621 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDMAN, SCOTT L. · 2000 to 2019
$6.2M
Transcriptional and developmental regulation of placental fuel storage and metabP01HD069316 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI BARAK, YAACOV · 2012 to 2016
$5.0M
Transcriptional Control of Placental DevelopmentR01HD044103 · NICHD · JACKSON LABORATORY · PI BARAK, YAACOV · 2003 to 2007
$1.4M
Reproductive Development from Gonads to FetusesT32HD087194 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2017 to 2021
$925k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA014195NHLBI NIH HHS P01 HL088093NICHD NIH HHS P01 HD069316NICHD NIH HHS R01 HD044103NICHD NIH HHS T32 HD087194NIDDK NIH HHS R01 DK056621NIDDK NIH HHS R37 DK057978
6 · The paper itself

Abstract

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is an essential regulator of placental development. To gain deeper insights into placental PPARγ signaling, we dissected its regulation of the

Indexed as

AnimalsCarrier ProteinsCell LineCo-Repressor ProteinsFemaleGene Expression RegulationHEK293 CellsHumansKruppel-Like Factor 6LigandsMiceMice, Inbred C57BLMucin-1PPAR gammaPregnancyPromoter Regions, GeneticCarrier ProteinsCo-Repressor ProteinsKLF6 protein, humanKruppel-Like Factor 6LCOR protein, humanLigandsMUC1 protein, humanMucin-1PPAR gammaRepressor ProteinsRetinoid X Receptor alphaRetinoid X ReceptorscoactivatorsKLF6LCoRPPARgammarexinoidsRXRtranscription regulation

Identifiers

PMID29463649
PMCPMC5902596
OpenAlexW2791959216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.