Evidence map›Paper›PMID 29463641›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System.

Jan Kubanek, Poojan Shukla, Alakananda Das, Stephen A Baccus, Miriam B Goodman

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05145426 (Investigation of Low-intensity Focused Ultrasound for Human Pain Management), which is not on this map. Cited by 160 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05145426 nacompletednot on this mapstarted 2022, after this paper: background citation

Investigation of Low-intensity Focused Ultrasound for Human Pain Management

TypeinterventionalSponsorVirginia Polytechnic Institute and State UniversityRan2022 to 2025Enrolled61ConditionsChronic PainArmsLow Intensity Focused Ultrasound
3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 1 synthesis or guideline pooled it, 309 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jan KubanekDepartment of Molecular and Cellular Physiology and.ORCID 0000-0003-0527-5559
Poojan ShuklaDepartment of Molecular and Cellular Physiology and.
Alakananda DasDepartment of Molecular and Cellular Physiology and.ORCID 0000-0003-3672-3895
Stephen A BaccusDepartment of Neurobiology, Stanford, California 94305.ORCID 0000-0001-8692-5685
Miriam B GoodmanDepartment of Molecular and Cellular Physiology and mbgoodman@stanford.edu.ORCID 0000-0002-5810-1272
Stanford Medicine · USStanford University · US

Funding

The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
Molecular Basis of Sensory Transduction in C. elegansR01NS047715 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2004 to 2017
$4.9M
Neurostimulation by Ultrasound: Physical, Biophysical and Neural MechanismsR01EB019005 · NIBIB · STANFORD UNIVERSITY · PI BACCUS, STEPHEN A, BUTTS-PAULY, KIM · 2014 to 2017
$2.8M
Request to purchase replace cryogenic storage equipment to preserve biological reagents.R01NS092099 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2015 to 2017
$1.1M
Ultrasonic Neuromodulation: From Mechanism To Optimal ApplicationK99NS100986 · NINDS · STANFORD UNIVERSITY · PI KUBANEK, JAN · 2017 to 2018
$175k
NIBIB NIH HHS R01 EB019005NINDS NIH HHS K99 NS100986NINDS NIH HHS R01 NS047715NINDS NIH HHS R01 NS092099NINDS NIH HHS R35 NS105092
6 · The paper itself

Abstract

Focused ultrasound has been shown to stimulate excitable cells, but the biophysical mechanisms behind this phenomenon remain poorly understood. To provide additional insight, we devised a behavioral-genetic assay applied to the well-characterized nervous system of

Indexed as

Ultrasonic WavesAnimalsBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsMembrane ProteinsNeuronsTouchCaenorhabditis elegans ProteinsMec-4 protein, C elegansMembrane ProteinsCaenorhabditis elegansmechanosensationmechanosensitive ion channelsneurostimulationthermosensationultrasound

Identifiers

PMID29463641
PMCPMC5864152
OpenAlexW2950954824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.