Evidence map›Paper›PMID 29463595›Full record

ArticleMolecular & cellular proteomics : MCP2018

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells.

Twishi Gulati, Cheng Huang, Franco Caramia, Dinesh Raghu, Piotr J Paul, Robert J A Goode, Simon P Keam, Scott G Williams, Sue Haupt, Oded Kleifeld and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Twishi GulatiFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
Cheng Huang¶Monash Biomedical Proteomics Facility, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Franco Caramia§Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Dinesh RaghuFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
Piotr J PaulFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
Robert J A Goode¶Monash Biomedical Proteomics Facility, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Simon P Keam§Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Scott G Williams‖Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Sue HauptFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
Oded Kleifeld**Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Ralf B Schittenhelm¶Monash Biomedical Proteomics Facility, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Cristina GamellFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
Ygal HauptFrom the ‡The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia; ygal.haupt@petermac.org.
Peter MacCallum Cancer Centre · AUUniversity of Melbourne · AUMonash University · AUAustralian Regenerative Medicine Institute · AUTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is a common cause of cancer-related death in men. E6AP (E6-Associated Protein), an E3 ubiquitin ligase and a transcription cofactor, is elevated in a subset of prostate cancer patients. Genetic manipulations of E6AP in prostate cancer cells expose a role of E6AP in promoting growth and survival of prostate cancer cells

Indexed as

AnimalsCell LineClusterinGene Knockdown TechniquesHumansMaleMiceNeoplasm ProteinsProstatic NeoplasmsProteomicsTranscriptomeUbiquitin-Protein LigasesCLU protein, humanClusterinNeoplasm ProteinsUBE3A protein, humanUbiquitin-Protein LigasesClusterinE6APProstate cancerProtein Identification*ProteomicsSILACTranscription*TranscriptomicsUbiquitinases

Identifiers

PMID29463595
PMCPMC5986238
OpenAlexW2791567807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.