Evidence map›Paper›PMID 29463544›Full record

ArticleAntimicrobial agents and chemotherapy2018

Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation.

Melanie T Cushion, Alan Ashbaugh, Keeley Hendrix, Michael J Linke, Nikeya Tisdale, Steven G Sayson, Aleksey Porollo

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Advances in pathogen detection ofInfectious medicine · 2025
    Review
  2. Article
  3. JHLT open · 2025
    Article
  4. Article
  5. mBio · 2024
    Article
  6. NovelJournal of fungi (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Targeted NGS-Based Analysis ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  9. Journal of fungi (Basel, Switzerland) · 2022
    Review
  10. Transmission and Colonization ofJournal of fungi (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Pneumocystis Mating-Type Locus and Sexual Cycle during Infection.Microbiology and molecular biology reviews : MMBR · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Caspofungin andAntimicrobial agents and chemotherapy · 2019
    Article
  19. Review
  20. The 14th International Workshops on Opportunistic Protists (IWOP 14).The Journal of eukaryotic microbiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Melanie T Cushion *Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Melanie.Cushion@uc.edu.ORCID 0000-0001-6621-2784
Alan AshbaughDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-8373-439X
Keeley HendrixDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Michael J LinkeThe Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
Nikeya TisdaleDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-5919-129X
Steven G SaysonDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-7461-0704
Aleksey Porollo *Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-3202-5099
University of Cincinnati Medical Center · USVeterans Health Administration · USCincinnati Children's Hospital Medical Center · US

Funding

Immunopathology of the Pneumocystis Life Cycle StagesI01BX000523 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI CUSHION, MELANIE T · 2011 to 2014
–
BLRD VA I01 BX000523BLRD VA I01 BX004441BLRD VA IK6 BX005232
6 · The paper itself

Abstract

The echinocandins are a class of antifungal agents that target β-1,3-d-glucan (BG) biosynthesis. In the ascigerous

Indexed as

AnidulafunginAnimalsAntifungal AgentsCell Cycle CheckpointsCell ProliferationCell WallMaleMicePneumocystisPneumonia, PneumocystisAnidulafunginAntifungal AgentsAIDS relatedanidulafunginantifungal agentsascusechinocandinopportunistic fungiPneumocystisPneumocystis pneumoniasexual development

Identifiers

PMID29463544
PMCPMC5923105
OpenAlexW2791106942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.