Evidence map›Paper›PMID 29463543›Full record

ArticleAntimicrobial agents and chemotherapy2018

Mesoscopic Energy Minimization Drives Pseudomonas aeruginosa Biofilm Morphologies and Consequent Stratification of Antibiotic Activity Based on Cell Metabolism.

M V Sheraton, J K H Yam, C H Tan, H S Oh, E Mancini, L Yang, S A Rice, P M A Sloot

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M V SheratonComplexity Institute, Nanyang Technological University, Singapore.
J K H YamSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.
C H TanSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.
H S OhSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.
E ManciniInstitute for Advanced Study, University of Amsterdam, Amsterdam, The Netherlands.
L YangSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.ORCID 0000-0002-2362-0128
S A RiceSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.ORCID 0000-0002-9486-2343
P M A SlootComplexity Institute, Nanyang Technological University, Singapore p.m.a.sloot@uva.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Segregation of bacteria based on their metabolic activities in biofilms plays an important role in the development of antibiotic resistance. Mushroom-shaped biofilm structures, which are reported for many bacteria, exhibit topographically varying levels of multiple drug resistance from the cap of the mushroom to its stalk. Understanding the dynamics behind the formation of such structures can aid in design of drug delivery systems, antibiotics, or physical systems for removal of biofilms. We explored the development of metabolically heterogeneous

Indexed as

Anti-Bacterial AgentsBiofilmsPseudomonas aeruginosaAnti-Bacterial Agentsantibiotic resistancebiofilmscell motilitycell proliferationcellular Potts modelchemotaxismushroom-shaped biofilmPseudomonas aeruginosa

Identifiers

PMID29463543
PMCPMC5923133

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.