Evidence map›Paper›PMID 29463541›Full record

ArticleAntimicrobial agents and chemotherapy2018

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.

Chao Chen, Susana Gardete, Robert Sander Jansen, Annanya Shetty, Thomas Dick, Kyu Y Rhee, Véronique Dartois

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  5. Article
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  7. Article
  8. Review
  9. Article
  10. Verapamil and its metabolite norverapamil inhibit theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Evolution of Small Molecule Inhibitors ofJournal of medicinal chemistry · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
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  18. Review
  19. Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chao ChenPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Susana GardeteWeill Cornell Medical College, Weill Department of Medicine, New York, New York, USA.
Robert Sander JansenWeill Cornell Medical College, Weill Department of Medicine, New York, New York, USA.
Annanya ShettyDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Thomas DickPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.ORCID 0000-0002-9604-9452
Kyu Y RheeWeill Cornell Medical College, Weill Department of Medicine, New York, New York, USA.
Véronique DartoisPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA veronique.dartois@rutgers.edu.
Cornell University · USRutgers, The State University of New Jersey · USNational University of Singapore · SG

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASANOVA, JEAN-LAURENT, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
Target based discovery of next generation pyrazinamideR01AI106398 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DICK, THOMAS · 2013 to 2022
$7.1M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
NIAID NIH HHS R01 AI106398NIAID NIH HHS U19 AI111143NIH HHS S10 OD023524
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntitubercular AgentsCalcium Channel BlockersCell MembraneClofazimineDiarylquinolinesDrug SynergismFemaleHumansMiceMicrobial Sensitivity TestsMycobacterium tuberculosisVerapamilAntitubercular AgentsbedaquilineCalcium Channel BlockersClofazimineDiarylquinolinesVerapamilbioenergeticsefflux pumpMycobacterium tuberculosisverapamil

Identifiers

PMID29463541
PMCPMC5923092
OpenAlexW2789815570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.