ArticleVeterinary research2018
Lysozyme improves gut performance and protects against enterotoxigenic Escherichia coli infection in neonatal piglets.
Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Lactoferrin and lysozyme for Kenyan children presenting with wasting and diarrhea: A 2 × 2 factorial randomized controlled trial.medRxiv : the preprint server for health sciences · 2026Article
- Alleviating Clostridium perfringens-Induced Gut Lesionsin Broiler Chickens by Orally Administered Bovine Intestinal Alkaline Phosphatase.Probiotics and antimicrobial proteins · 2026Article
- Dietary Supplementation with Yak Stomach Lysozyme Improves Intestinal Health and Nutrient Metabolism in Weaned Piglets Challenged with EnterotoxigenicAnimals : an open access journal from MDPI · 2025Article
- Gene Editing for Enhanced Swine Production: Current Advances and Prospects.Animals : an open access journal from MDPI · 2025Review
- Host-microbiota interactions in the infant gut revealed by daily faecal sample time series.Microbiome research reports · 2025Article
- Consortium ofAntibiotics (Basel, Switzerland) · 2024Article
- Article
- Identification of Copy Number Variations and Selection Signatures in Wannan Spotted Pigs by Whole Genome Sequencing Data: A Preliminary Study.Animals : an open access journal from MDPI · 2024Article
- Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024Review
- Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs.Frontiers in microbiology · 2024Article
- Dietary Supplementation with Lysozyme-Cinnamaldehyde Conjugates Enhances Feed Conversion Efficiency by Improving Intestinal Health and Modulating the Gut Microbiota in Weaned Piglets Infected with EnterotoxigenicAnimals : an open access journal from MDPI · 2023Article
- Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Isolation, characterization and whole genome analysis of the novel genus Lederbergvirus, phage vB_EcoP_E212 infecting enterotoxigenic Escherichia coli K88.Virus research · 2023Article
- Gut Health and Influencing Factors in Pigs.Animals : an open access journal from MDPI · 2023Review
- Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice.Nutrients · 2023Article
- Article
- Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs.Genetics, selection, evolution : GSE · 2022Article
- Characterization of Recombinant Antimicrobial Peptide BMGlv2 Heterologously Expressed inInternational journal of molecular sciences · 2022Article
- Recombinant expression of hen egg white lysozyme with the assistance of xylanase fusion partner inBioengineered · 2022Article
- Improvements in pig agriculture through gene editing.CABI agriculture and bioscience · 2022Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets. We found that consuming hLZ milk facilitated faster recovery from infection and decreased mortality and morbidity following an ETEC oral inoculation or infection acquired by contact-exposure. The protective effect of hLZ was associated with the enrichment of intestinal bacteria that improve gut health, such as Lactobacillus, and the enhancement of the mucosal IgA response to the ETEC-induced diarrhea. Our study revealed potential protective mechanisms underlying the antimicrobial activity of human lysozyme, validating the use of lysozyme as an effective preventive measure for diarrhea.
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