ArticleBMC complementary and alternative medicine2018
Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Synthesis and biological evaluation of tris(4-methoxyphenyl)phosphonium-hydrazone derivatives against clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates: antibacterial, antibiofilm, and gene expression analyses.Folia microbiologica · 2026Article
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- Phytochemical Analysis of Different Plant Organs of Bauhinia kockiana Korth. and Its Antibacterial Synergistic Interaction.Applied biochemistry and biotechnology · 2026Article
- Advances in phytochemical-derived nanotherapeutics for multimodal eradication of multidrug-resistantFrontiers in pharmacology · 2026Review
- Antimicrobial Activities of Propolis Nanoparticles in Combination with Ampicillin Sodium Against Methicillin-ResistantMicroorganisms · 2025Article
- Biosynthesis of bimetallic silver-copper oxide nanoparticles using endophyticFrontiers in microbiology · 2025Article
- Antibacterial activity of structurally diverse natural prenylated isobavachalcone derivatives.RSC advances · 2024Article
- Gallic acid exerts antibiofilm activity by inhibiting methicillin-resistant Staphylococcus aureus adhesion.Scientific reports · 2024Article
- Plant-Based Films and Hydrogels for Wound Healing.Microorganisms · 2024Review
- Comparison of Antibacterial Activity of Phytochemicals against Common Foodborne Pathogens and Potential for Selection of Resistance.Microorganisms · 2023Article
- Antibacterial and Antimycotic Activity ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Methicillin-ResistantIranian journal of public health · 2023Review
- Antibacterial efficacy ofJournal of food science and technology · 2023Article
- Harnessing the Role of Bacterial Plasma Membrane Modifications for the Development of Sustainable Membranotropic Phytotherapeutics.Membranes · 2022Review
- Article
- Graphene Oxide affects Staphylococcus aureus and Pseudomonas aeruginosa dual species biofilm in Lubbock Chronic Wound Biofilm model.Scientific reports · 2020Article
- Hexyl gallate for the control of citrus canker caused by Xanthomonas citri subsp citri.MicrobiologyOpen · 2020Article
- Tellimagrandin II, A Type of Plant Polyphenol Extracted fromInternational journal of molecular sciences · 2019Article
- Discovery of Potential Plant-Derived Peptide Deformylase (PDF) Inhibitors for Multidrug-Resistant Bacteria Using Computational Studies.Journal of clinical medicine · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBauhinia kockiana originates from Peninsular Malaysia and it is grown as a garden ornamental plant. Our previous study reported that this plant exhibited fairly strong antioxidant and antimicrobial activities. This paper focused on the assessment of the antibacterial activity of B. kockiana towards methicillin-resistance Staphylococcus aureus (MRSA), to purify and to identify the antibacterial compounds, and to determine the mechanism of antibacterial activity.
methodsAntibacterial activity of B. kockiana flower was evaluated qualitatively and quantitatively using disc diffusion assay and microbroth dilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of extracts were examined. Phytochemical analysis was performed to determine the classes of phytochemicals in the extracts. Bioactivity guided isolation was employed to purify the antibacterial agents and identified via various spectroscopy methods. Scanning electron microscopy (SEM) technique was used to evaluate the antibacterial mechanism of extract and compounds isolated.
resultsB. kockiana flower was found to exhibit fairly strong antibacterial activity towards both strains of MRSA bacteria used, MIC varies from 62.5-250 μg/mL. Tannins and flavonoids have been detected in the phytochemical analysis. Gallic acid and its ester derivatives purified from ethyl acetate extract could inhibit MRSA at 250-500 μg/mL. SEM revealed that the cells have undergone plasmolysis upon treatment with the extract and compounds.
conclusionTannins and polyphenols are the antibacterial components towards MRSA in B. kockiana. Massive leakage of the cell content observed in treated cells showed that the phytochemicals have changed the properties of the cell membranes. Amphiphilic nature of the compounds exhibited the antibacterial activity towards MRSA via three stages: (1) cell membrane attachment; (2) cell membrane fluidity modification; and (3) cell membrane structure disruption.
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