Evidence map›Paper›PMID 29463181›Full record

ArticleJournal of clinical and experimental neuropsychology2018

Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.

Lucas S Broster, Juan Li, Benjamin Wagner, Charles D Smith, Gregory A Jicha, Frederick A Schmitt, Nancy Munro, Ryan H Haney, Yang Jiang

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lucas S Brostera Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Juan Lia Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Benjamin Wagnera Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Charles D Smithd Department of Neurology , University of Kentucky College of Medicine , Lexington , KY , USA.
Gregory A Jichad Department of Neurology , University of Kentucky College of Medicine , Lexington , KY , USA.
Frederick A Schmittb Department of Psychiatry , University of California , San Francisco , CA , USA.
Nancy Munrog Oak Ridge National Laboratory , Oak Ridge , TN , USA.
Ryan H Haneya Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Yang Jianga Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
University of Kentucky · USInstitute of Psychology, Chinese Academy of Sciences · CNOak Ridge National Laboratory · USUniversity of California, San Francisco · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI JICHA, GREGORY A · 2006 to 2020
$23.3M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
TRAINING AND INFORMATION TRANSFER COREP50AG005144 · NIA · UNIVERSITY OF KENTUCKY · PI MARKESBERY, WILLIAM R · 1985 to 2005
$8.9M
TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
Neuroimaging of Complex Motion in Young and Old AdultsK01AG000986 · NIA · UNIVERSITY OF KENTUCKY · PI JIANG, YANG · 2001 to 2005
$584k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCRR NIH HHS UL1 RR033173NIA NIH HHS K01 AG000986NIA NIH HHS P30 AG028383NIA NIH HHS P50 AG005144NIMH NIH HHS R25 MH060482
6 · The paper itself

Abstract

objectiveIndividuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex.

methodParticipants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects.

resultsParticipants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect.

conclusionVisual cortex may play a role in maintained repetition effects in persons with early AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCerebral CortexCognitive DysfunctionCohort StudiesElectroencephalographyFemaleHumansMaleMemory, Short-TermPhotic StimulationPsychomotor PerformanceReaction TimeVisual CortexAlzheimer’s diseaseevent-related potentialsmild cognitive impairmentrepetition effectsworking memory

Identifiers

PMID29463181
PMCPMC6397625
OpenAlexW2789620788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.