Evidence map›Paper›PMID 29462980›Full record

ArticleToxins2018

Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study.

Juan Carlos Quintana-Castillo, Leidy Johana Vargas, Cesar Segura, Sebastian Estrada-Gómez, Julio César Bueno-Sánchez, Juan Carlos Alarcón

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Brief history of ophidiology and ophidism in Colombia.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Juan Carlos Quintana-CastilloSchool of Medicine, Universidad Cooperativa de Colombia, Sede Medellín, Street 50 A N° 41-20, Medellín 050010, Colombia. juan.quintanac@ucc.edu.co.ORCID 0000-0002-7923-9158
Leidy Johana VargasSchool of Medicine, Universidad Cooperativa de Colombia, Sede Medellín, Street 50 A N° 41-20, Medellín 050010, Colombia. leidy.vargasmu@campusucc.edu.co.
Cesar SeguraMalaria Group, School of Medicine, University of Antioquia UdeA, Street 70 N° 52-21, Medellín 050010, Colombia. cesars79@gmail.com.ORCID 0000-0002-9979-8416
Sebastian Estrada-GómezOphidism/Scorpionism Program, Food and Pharmaceutical Sciences Faculty, University of Antioquia UdeA, Street 70 N° 52-21, Medellín 050010, Colombia. sebastian.estrada@udea.edu.co.ORCID 0000-0002-7326-5873
Julio César Bueno-SánchezReproduction Group, School of Medicine, University of Antioquia UdeA, Street 70 N° 52-21, Medellín 050010, Colombia. julio.bueno@yahoo.com.
Juan Carlos AlarcónOphidism/Scorpionism Program, Food and Pharmaceutical Sciences Faculty, University of Antioquia UdeA, Street 70 N° 52-21, Medellín 050010, Colombia. juan.alarcon@udea.edu.co.
Universidad de Antioquia · COUniversidad Cooperativa de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity.

Indexed as

CrotalusAnimalsAntiveninsColombiaCrotalid VenomsProteomicsReptilian ProteinsAntiveninsCrotalid VenomsReptilian ProteinsantivenomC. d. cumanensis venomHPLC-nESI-MS/MSpeptide identification

Identifiers

PMID29462980
PMCPMC5848186
OpenAlexW2793085160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.