ArticleInternational journal of molecular sciences2018
A Biochemical Approach to Detect Oxidative Stress in Infertile Women Undergoing Assisted Reproductive Technology Procedures.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
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- Mendelian randomization in ovarian research: applications in PCOS, ovarian aging, and assisted reproductive technology.Journal of ovarian research · 2026Review
- Oxidative stress biomarkers in assisted reproductive technologies: From follicular redox biology to clinical translation.Redox biology · 2026Review
- Comparing the Effects of Glyphosate and Mycotoxins in the Human Follicular Microenvironment: An Exploratory Exposome Study.Biomedicines · 2026Article
- Elevated Salivary Antioxidant Biomarkers are Favorable for Clinical Pregnancy in Women Undergoing IVF: A Prospective Cohort Study.Health science reports · 2026Article
- Endometriosis and infertility: pathophysiology, treatment strategies, and reproductive outcomes.Archives of gynecology and obstetrics · 2025Review
- Factorial analysis of zinc serum levels, fatty acids, oxidative stress parameters and supplementation on assisted reproductive technology outcome.Journal of medical biochemistry · 2025Article
- The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study.International journal of reproductive biomedicine · 2024Article
- Fibrinogen Structural Changes and Their Potential Role in Endometriosis-Related Thrombosis.Antioxidants (Basel, Switzerland) · 2024Article
- The Efficacy and Safety of GF101 and Its Antioxidant Effect on In Vitro Fertilization Outcomes: A Double-Blind, Non-Inferiority, Randomized, Controlled Trial with Coenzyme Q10.Antioxidants (Basel, Switzerland) · 2024Article
- Can follicular fluid 8-oxo-2'-deoxyguanosine predict the clinical outcomes in ICSI cycle among couples with normospermia male?Obstetrics & gynecology science · 2023Article
- Blood Leukocyte ROS Production Reflects Seminal Fluid Oxidative Stress and Spermatozoa Dysfunction in Idiopathic Infertile Men.Antioxidants (Basel, Switzerland) · 2023Article
- Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder.Biomedicines · 2023Article
- Unraveling female reproductive senescence to enhance healthy longevity.Cell research · 2023Review
- Endometriosis and Infertility: A Long-Life Approach to Preserve Reproductive Integrity.International journal of environmental research and public health · 2022Review
- A unique circulating miRNA profile highlights thrombo-inflammation in Behçet's syndrome.Annals of the rheumatic diseases · 2022Article
- He's Yangchao Recipe Ameliorates Ovarian Oxidative Stress of Aging Mice under Consecutive Superovulation Involving JNK- And P53-Related Mechanism.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Age-Dependent Metabolomic Profile of the Follicular Fluids From Women Undergoing Assisted Reproductive Technology Treatment.Frontiers in endocrinology · 2022Article
- Metformin promotesFrontiers in cell and developmental biology · 2022Article
- Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome.Clinical and experimental immunology · 2021Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress plays a major role in critical biological processes in human reproduction. However, a reliable and biologically accurate indicator of this condition does not yet exist. On these bases, the aim of this study was to assess and compare the blood and follicular fluid (FF) redox status of 45 infertile subjects (and 45 age-matched controls) undergoing in vitro fertilization (IVF), and explore possible relationships between the assessed redox parameters and IVF outcomes. Reactive Oxygen Species (ROS) production, assessed by flow cytometry analysis in blood leukocytes and granulosa cells, significantly increased (p < 0.05) in infertile patients. Also, oxidative stress markers-ThioBarbituric Acid-Reactive Substances (TBARS) as an index of lipid peroxidation, and Oxygen Radical Absorbance Capacity (ORAC) to account for total antioxidant capacity, both assayed by fluorometric procedures-in blood and FF were significantly (p < 0.001) modified in infertile patients compared to the control group. Moreover, a significant correlation between blood redox markers and FF redox markers was evident. An ORAC/TBARS ratio, defined as the redox index (RI), was obtained in the plasma and FF of the patients and controls. In the patients, the plasma RI was about 3.4-fold (p < 0.0001) lower than the control, and the FF RI was about six-fold (p < 0.0001) lower than the control. Interestingly, both the plasma RI and FF RI results were significantly correlated (p < 0.05) to the considered outcome parameters (metaphase II, fertilization rate, and ongoing pregnancies). Given the reported findings, a strict monitoring of redox parameters in assisted reproductive techniques and infertility management is recommended.
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Registered trials
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