Evidence map›Paper›PMID 29462896›Full record

ArticleGenes2018

Dietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesis.

Faraz Bishehsari, Phillip A Engen, Nailliw Z Preite, Yunus E Tuncil, Ankur Naqib, Maliha Shaikh, Marco Rossi, Sherry Wilber, Stefan J Green, Bruce R Hamaker and 4 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 106 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05906589 nacompletednot on this mapstarted 2023, after this paper: background citation

Exploring Mechanism of Action of Dietary Fibre on the Gut Microbiota and Metabolites: Can we Identify Responders and Non-responders to Psyllium and Inulin Dietary Fibres?

TypeinterventionalSponsorUniversity of AberdeenRan2023 to 2025Enrolled40ConditionsPsyllium, InulinArmsInulin, Psyllium, Maltodextrin
NCT07790003 completednot on this mapstarted 2024, after this paper: background citation

Dietary Fibre Supplementation to Delay Disease Progression in Early Prostate Cancer

TypeobservationalSponsorUniversity of AberdeenRan2024 to 2024Enrolled10ConditionsProstate Cancer, Prostatic Neoplasm, Dietary Fibre Modification, Active SurveillanceArmsQualitative semi-structured interviews, Focus group
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Zearalenone exposure and the mammalian gut microbiome: a systematic review of the literature.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Pooled it
  2. Pooled it
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  5. Broccoli consumption affects the human gastrointestinal microbiota.The Journal of nutritional biochemistry · 2019
    Trial
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Faraz BishehsariDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Faraz_Bishehsari@rush.edu.
Phillip A EngenDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Phillip_Engen@rush.edu.
Nailliw Z PreiteDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Nailliw_Preite@rush.edu.ORCID 0000-0002-0675-9080
Yunus E TuncilWhistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN USA. yunustuncil@odu.edu.tr.ORCID 0000-0002-9421-2332
Ankur NaqibDNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, IL USA. anaqib2@uic.edu.
Maliha ShaikhDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Maliha_Shaikh@rush.edu.
Marco RossiDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Marco_Rossi@rush.edu.
Sherry WilberDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Sherry_Wilber@rush.edu.
Stefan J GreenDNA Services Facility, Research Resources Center, University of Illinois at Chicago, Chicago, IL USA. greendna@uic.edu.ORCID 0000-0003-2781-359X
Bruce R HamakerWhistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN USA. hamakerb@purdue.edu.
Khashayarsha KhazaieDepartment of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. Khazaie@mayo.edu.
Robin M VoigtDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Robin_Voigt@rush.edu.
Christopher B ForsythDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Christopher_Forsyth@rush.edu.
Ali KeshavarzianDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL USA. Ali_Keshavarzian@rush.edu.

Funding

How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - RenewalR01AI108682 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI, KHAZAIE, KHASHAYARSHA · 2014 to 2024
$5.1M
Brain-gut circadian rhythm interactions in alcohol-induced gut leakinessR01AA020216 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI KESHAVARZIAN, ALI, TUREK, FRED W · 2010 to 2014
$3.0M
Role of Alcohol and Circadian Disruption in Inflammation and Colon CancerR01AA023417 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI KESHAVARZIAN, ALI, KHAZAIE, KHASHAYARSHA · 2014 to 2018
$2.0M
NIAAA NIH HHS R01 AA020216NIAAA NIH HHS R01 AA023417NIAID NIH HHS R01 AI108682
6 · The paper itself

Abstract

Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC). One possible mechanism of fiber is its fermentation property in the gut and ability to change microbiota composition and function. Here, we investigate the role of a dietary fiber mixture in polyposis and elucidate potential mechanisms using TS4Cre×cAPC

Indexed as

butyrateCRCdietary fibermicrobiotaSCFA

Identifiers

PMID29462896
PMCPMC5852598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.