Evidence map›Paper›PMID 29462891›Full record

ArticleSensors (Basel, Switzerland)2018

Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules.

Christian Hundshammer, Stephan Düwel, David Ruseckas, Geoffrey Topping, Piotr Dzien, Christoph Müller, Benedikt Feuerecker, Jan B Hövener, Axel Haase, Markus Schwaiger and 2 more

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Performance and reproducibility ofScientific reports · 2022
    Article
  6. Chemical science · 2021
    Article
  7. Parahydrogen-Induced Polarization of Amino Acids.Angewandte Chemie (International ed. in English) · 2021
    Review
  8. Review
  9. HyperpolarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2020
    Article
  10. Article
  11. Review
  12. Application ofBioconjugate chemistry · 2020
    Article
  13. Cardiac pH-Imaging With Hyperpolarized MRI.Frontiers in cardiovascular medicine · 2020
    Review
  14. HyperpolarizedOncotarget · 2019
    Article
  15. Article
  16. Review
  17. Hyperpolarized [6-ACS chemical biology · 2019
    Article
  18. A non-synthetic approach to extending the lifetime of hyperpolarized molecules using DJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christian HundshammerDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. christian.hundshammer@tum.de.ORCID 0000-0002-6738-1560
Stephan DüwelDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. stephan.duewel@tum.de.ORCID 0000-0002-5491-4866
David RuseckasDepartment of Chemistry, Technical University of Munich, 85748 Garching, Germany. david.ruseckas@mnet-online.de.
Geoffrey ToppingDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. geoff.topping@lrz.tu-muenchen.de.
Piotr DzienDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. realtoughmonkey1980@gmail.com.
Christoph MüllerDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. christoph.mueller.rdiag@uniklinik-freiburg.de.
Benedikt FeuereckerDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. benedikt.feuerecker@mytum.de.
Jan B HövenerSection for Biomedical Imaging, Molecular Imaging North Competence Center (MOINCC), Department for Radiology and Neuroradiology, University Medical Center Kiel, University Kiel, 24118 Kiel, Germany. jan.hoevener@rad.uni-kiel.de.
Axel HaaseMunich School of Bioengineering, Technical University of Munich, 85748 Garching, Germany. axel.haase@tum.de.
Markus SchwaigerDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. markus.schwaiger@tum.de.
Steffen J GlaserDepartment of Chemistry, Technical University of Munich, 85748 Garching, Germany. glaser@tum.de.
Franz SchillingDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 München, Germany. fschilling@tum.de.ORCID 0000-0001-5239-4628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

pH is a tightly regulated physiological parameter that is often altered in diseased states like cancer. The development of biosensors that can be used to non-invasively image pH with hyperpolarized (HP) magnetic resonance spectroscopic imaging has therefore recently gained tremendous interest. However, most of the known HP-sensors have only individually and not comprehensively been analyzed for their biocompatibility, their pH sensitivity under physiological conditions, and the effects of chemical derivatization on their logarithmic acid dissociation constant (p

Indexed as

amino acidsdissolution dynamic nuclear polarizationhyperpolarizedmagnetic resonance spectroscopic imagingnuclear magnetic resonancepH sensors

Identifiers

PMID29462891
PMCPMC5856118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.