ArticleDrug and alcohol dependence2018
Psychosocial and neural indicators of resilience among youth with a family history of substance use disorder.
Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- Environmentally derived subgroups of preadolescents with family history of substance use exhibit distinct patterns of psychopathology and reward-related behaviors: insights from the ABCD study.Frontiers in child and adolescent psychiatry · 2025Article
- Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use.Frontiers in psychiatry · 2025Review
- The role of resilience in the relationship between stress and alcohol.Neurobiology of stress · 2024Article
- Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing.Psychopharmacology · 2024Article
- Neural response to threat and reward among young adults at risk for alcohol use disorder.Addiction biology · 2024Article
- NEURAL RESPONSE TO THREAT AND REWARD AMONG YOUNG ADULTS AT RISK FOR ALCOHOL USE DISORDER.medRxiv : the preprint server for health sciences · 2023Article
- Religious affiliation protects against alcohol/substance use initiation: A prospective study among healthy adolescents.Journal of adolescence · 2023Article
- Emotion regulation in young adults with family history of harmful alcohol use: A fMRI study.Drug and alcohol dependence · 2023Article
- Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood.Addiction and substance abuse · 2023Article
- Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD StudyBrain sciences · 2022Article
- Effects of family history of substance use disorder on reward processing in adolescents with and without attention-deficit/hyperactivity disorder.Addiction biology · 2022Article
- "I Grew Up Amidst Alcohol and Drugs:" a Qualitative Study on the Lived Experiences of Parental Substance Use Among Adults Who Developed Substance Use Disorders Themselves.Frontiers in psychiatry · 2022Article
- Understanding the Etiology of Adolescent Substance Use through Developmental Perspectives.Child development perspectives · 2021Article
- Interactions between methodological and interindividual variability: How Monetary Incentive Delay (MID) task contrast maps vary and impact associations with behavior.Brain and behavior · 2021Article
- Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence.International review of neurobiology · 2021Review
- Brain networks underlying vulnerability and resilience to drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cognitive Modeling Informs Interpretation of Go/No-Go Task-Related Neural Activations and Their Links to Externalizing Psychopathology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
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4 authors.
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Abstract
backgroundLittle is known regarding the combined influence of psychosocial and neural protective mechanisms against substance use. The present study examined the extent to which neuroimaging measures of disinhibition predicted resilience against binge drinking and marijuana use among youth with a family history of substance use disorder (SUD; FH+), accounting for psychosocial measures of behavioral control.
methodsParticipants were 57 FH+ youth from the Michigan Longitudinal Study categorized into resilient and high-risk groups based on patterns of weekly binge drinking and monthly marijuana use during early adulthood. Psychosocial measures of behavioral control (reactive control and externalizing behavior during early and late adolescence) and neural measures of disinhibition (Go/No-Go task and Monetary Incentive Delay Task (MIDT) measured through functional magnetic resonance imaging (fMRI)) were entered sequentially in hierarchical logistic regression models to predict resilient versus high-risk groups.
resultsGreater activation in the right dorsolateral prefrontal cortex (DLPFC) during correctly inhibited trials on the Go/No-Go task was a significant predictor of resilience (OR = 2.46, p < 0.05), over and above greater reactive control in early adolescence (OR = 4.96, p < 0.05) and lower externalizing behavior in late adolescence (OR = 0.64, p < 0.05). Neural activation in the ventral striatum associated with reward anticipation during the MIDT was not a significant predictor of resilience.
conclusionsBrain function in the right DLPFC associated with inhibitory control may be a neural indicator of resilience against elevated substance use among FH+ youth, even after accounting for psychosocial measures of behavioral control.
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