Evidence map›Paper›PMID 29462554›Full record

ReviewACS nano2018

Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics.

Emily B Ehlerding, Piotr Grodzinski, Weibo Cai, Christina H Liu

Abstract readReview
In one paragraph

Review in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 146 citations in OpenAlex.

  1. Article
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  14. Functionalization ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  15. Biomaterials for Drug Delivery and Human Applications.Materials (Basel, Switzerland) · 2024
    Review
  16. Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  17. Review
  18. Responsive Nucleic Acid-Based Organosilica Nanoparticles.Journal of the American Chemical Society · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emily B EhlerdingOffice of Cancer Nanotechnology Research , National Cancer Institute, National Institutes of Health , Rockville , Maryland 20850 , United States.
Piotr GrodzinskiOffice of Cancer Nanotechnology Research , National Cancer Institute, National Institutes of Health , Rockville , Maryland 20850 , United States.
Christina H LiuOffice of Cancer Nanotechnology Research , National Cancer Institute, National Institutes of Health , Rockville , Maryland 20850 , United States.ORCID 0000-0002-5723-177X
National Institutes of Health · USUniversity of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

The importance of medical imaging in the diagnosis and monitoring of cancer cannot be overstated. As personalized cancer treatments are gaining popularity, a need for more advanced imaging techniques has grown significantly. Nanoparticles are uniquely suited to fill this void, not only as imaging contrast agents but also as companion diagnostics. This review provides an overview of many ways nanoparticle imaging agents have contributed to cancer imaging, both preclinically and in the clinic, as well as charting future directions in companion diagnostics. We conclude that, while nanoparticle-based imaging agents are not without considerable scientific and developmental challenges, they enable enhanced imaging in nearly every modality, hold potential as in vivo companion diagnostics, and offer precise cancer treatment and maximize intervention efficacy.

Indexed as

AnimalsBiomarkersContrast MediaHumansMagnetic Resonance ImagingNanoparticlesNeoplasmsOptical ImagingPhotoacoustic TechniquesPositron-Emission TomographyPrecision MedicineTheranostic NanomedicineTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUltrasonographyBiomarkersContrast Mediacancercompanion diagnosticscontrast agentEPR effectimagingmolecular imagingnanoparticlespersonalized medicinetheranostics

Identifiers

PMID29462554
PMCPMC5878691
OpenAlexW2788532043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.