ArticleAngewandte Chemie (International ed. in English)2018
Odorant Receptor 7D4 Activation Dynamics.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microbial volatile organic compounds and olfactory receptors in wound malodor.Frontiers in cellular and infection microbiology · 2026Pooled it
- Sensory-Chemical Co-Dynamics inFoods (Basel, Switzerland) · 2025Article
- Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.Current issues in molecular biology · 2024Article
- M2OR: a database of olfactory receptor-odorant pairs for understanding the molecular mechanisms of olfaction.Nucleic acids research · 2024Article
- Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors.Frontiers in molecular biosciences · 2024Review
- Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1.Journal of chemical information and modeling · 2023Article
- The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding.International journal of molecular sciences · 2022Article
- Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing.ACS central science · 2022Article
- Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors.International journal of molecular sciences · 2021Article
- Deconstructing the transmembrane core of class A G protein-coupled receptors.Trends in biochemical sciences · 2021Review
- Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (The Journal of biological chemistry · 2020Article
- Characterizing human odorant signals: insights from insect semiochemistry andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.Cellular and molecular life sciences : CMLS · 2020Article
- Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.Molecular and cellular neurosciences · 2020Article
- A two-stage computational approach to predict novel ligands for a chemosensory receptor.Current research in structural biology · 2020Article
- Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts.The Journal of biological chemistry · 2019Article
- Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase.Journal of visualized experiments : JoVE · 2019Article
- Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket.Cellular and molecular life sciences : CMLS · 2019Article
- Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.The journal of physical chemistry letters · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Deciphering how an odorant activates an odorant receptor (OR) and how changes in specific OR residues affect its responsiveness are central to understanding our sense of smell. A joint approach combining site-directed mutagenesis and functional assays with computational modeling has been used to explore the signaling mechanics of OR7D4. In this OR, a genetic polymorphism affects our perception of androstenone. Molecular simulations totaling 0.12 ms predicted that, similarly to observations for other G-protein-coupled receptors with known experimental structures, an activation pathway connects the ligand and the G-protein binding site. The 3D model activation mechanism correlates with in vitro data and notably predicts that the OR7D4 WM variant is not activated. Upon activation, an OR-specific sequence motif is the convergence point of the mechanism. Our study suggests that robust homology modeling can serve as a powerful tool to capture OR dynamics related to smell perception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.