ArticlePLoS pathogens2018
Divergent bornaviruses from Australian carpet pythons with neurological disease date the origin of extant Bornaviridae prior to the end-Cretaceous extinction.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Experimental infection of carpet pythons (Journal of virology · 2026Article
- ContinuousVirus evolution · 2026Article
- Wǔhàn sharpbelly bornavirus infects and persists in cypriniform cells.Journal of virology · 2025Article
- The diverse liver viromes of Australian geckos and skinks are dominated by hepaciviruses and picornaviruses and reflect host taxonomy and habitat.Virus evolution · 2024Article
- Evolutionary Analysis of a Parrot Bornavirus 2 Detected in a Sulphur-Crested Cockatoo (Animals : an open access journal from MDPI · 2023Article
- Diving deep into fish bornaviruses: Uncovering hidden diversity and transcriptional strategies through comprehensive data mining.Virus evolution · 2023Article
- Article
- Avian Bornavirus Research-A Comprehensive Review.Viruses · 2022Review
- Two novel bornaviruses identified in colubrid and viperid snakes.Archives of virology · 2021Article
- ICTV Virus Taxonomy Profile:The Journal of general virology · 2021Article
- Mapping the evolution of bornaviruses across geological timescales.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- 100-My history of bornavirus infections hidden in vertebrate genomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Metagenomic Snapshots of Viral Components in Guinean Bats.Microorganisms · 2021Article
- Virus-like insertions with sequence signatures similar to those of endogenous nonretroviral RNA viruses in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Metatranscriptomic Analysis of Virus Diversity in Urban Wild Birds with Paretic Disease.Journal of virology · 2020Article
- No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses.Virology journal · 2020Article
- Avian Bornaviral Ganglioneuritis: Current Debates and Unanswered Questions.Veterinary medicine international · 2020Review
- Investigation of astrovirus and bornavirus in the cerebrospinal fluid of dogs clinically diagnosed with meningoencephalitis of unknown etiology.Journal of veterinary internal medicine · 2020Article
- Article
- Evolution of Immune Systems From Viruses and Transposable Elements.Frontiers in microbiology · 2019Review
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue samples from Australian carpet pythons (Morelia spilota) with neurological disease were screened for viruses using next-generation sequencing. Coding complete genomes of two bornaviruses were identified with the gene order 3'-N-X-P-G-M-L, representing a transposition of the G and M genes compared to other bornaviruses and most mononegaviruses. Use of these viruses to search available vertebrate genomes enabled recognition of further endogenous bornavirus-like elements (EBLs) in diverse placental mammals, including humans. Codivergence patterns and shared integration sites revealed an ancestral laurasiatherian EBLG integration (77 million years ago [MYA]) and a previously identified afrotherian EBLG integration (83 MYA). The novel python bornaviruses clustered more closely with these EBLs than with other exogenous bornaviruses, suggesting that these viruses diverged from previously known bornaviruses prior to the end-Cretaceous (K-Pg) extinction, 66 MYA. It is possible that EBLs protected mammals from ancient bornaviral disease, providing a selective advantage in the recovery from the K-Pg extinction. A degenerate PCR primer set was developed to detect a highly conserved region of the bornaviral polymerase gene. It was used to detect 15 more genetically distinct bornaviruses from Australian pythons that represent a group that is likely to contain a number of novel species.
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