ArticlePLoS genetics2018
The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis.Journal of integrative plant biology · 2026Article
- Light-Controlled Seed Germination: Molecular Integration With Environmental Signals.Plant, cell & environment · 2026Review
- DOG1-Mediated Priming Followed by Environmentally Tunable Plasticity: A Two-Phase Model for Dormancy Establishment inProteomes · 2026Article
- Molecular mechanism of abscisic acid regulating bud-break through the NnTIFY10A/B-NnABI5 module in lotus.Horticulture research · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- SWEET1-mediated glucose transport is crucial for energy availability in Arabidopsis.The New phytologist · 2026Article
- Quiescin Sulfhydryl Oxidase-Like 1 Positively Regulates Seed Dormancy in Rice.Plant biotechnology journal · 2026Article
- COP9 Signalosome SubunitBiology · 2025Article
- COP9 Signalosome's Role in Plant Defense Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Under Blue Light Treatment, OsCSN2 Regulates the Phenotype of Rice Seedlings Through the GA Signaling Pathway.Plants (Basel, Switzerland) · 2025Article
- SmCSN5 is a synergist in the transcription factor SmMYB36-mediated biosynthesis of tanshinones and phenolic acids inHorticulture research · 2025Article
- Functional Characterization of OsCSN1 in the Agronomic Trait Control of Rice Seedlings Under Far-Red Light.International journal of molecular sciences · 2025Article
- Decoding the Transcriptomics of Oil Palm Seed Germination.Plants (Basel, Switzerland) · 2024Article
- Apple E3 ligase MdPUB23 mediates ubiquitin-dependent degradation of MdABI5 to delay ABA-triggered leaf senescence.Horticulture research · 2024Article
- EARLY FLOWERING is a dominant gain-of-function allele of FANTASTIC FOUR 1/2c that promotes early flowering in tomato.Plant biotechnology journal · 2024Article
- U-box E3 ubiquitin ligase PUB8 attenuates abscisic acid responses during early seedling growth.Plant physiology · 2023Article
- Plant deubiquitinases: from structure and activity to biological functions.Plant cell reports · 2023Review
- Genome-Wide Analysis of Wheat GATA Transcription Factor Genes Reveals Their Molecular Evolutionary Characteristics and Involvement in Salt and Drought Tolerance.International journal of molecular sciences · 2022Article
- Discovery of genetic loci and causal genes for seed germination via deep re-sequencing in soybean.Molecular breeding : new strategies in plant improvement · 2022Article
- Underlying Biochemical and Molecular Mechanisms for Seed Germination.International journal of molecular sciences · 2022Review
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
The control of seed germination and seed dormancy are critical for the successful propagation of plant species, and are important agricultural traits. Seed germination is tightly controlled by the balance of gibberellin (GA) and abscisic acid (ABA), and is influenced by environmental factors. The COP9 Signalosome (CSN) is a conserved multi-subunit protein complex that is best known as a regulator of the Cullin-RING family of ubiquitin E3 ligases (CRLs). Multiple viable mutants of the CSN showed poor germination, except for csn5b-1. Detailed analyses showed that csn1-10 has a stronger seed dormancy, while csn5a-1 mutants exhibit retarded seed germination in addition to hyperdormancy. Both csn5a-1 and csn1-10 plants show defects in the timely removal of the germination inhibitors: RGL2, a repressor of GA signaling, and ABI5, an effector of ABA responses. We provide genetic evidence to demonstrate that the germination phenotype of csn1-10 is caused by over-accumulation of RGL2, a substrate of the SCF (CRL1) ubiquitin E3 ligase, while the csn5a-1 phenotype is caused by over-accumulation of RGL2 as well as ABI5. The genetic data are consistent with the hypothesis that CSN5A regulates ABI5 by a mechanism that may not involve CSN1. Transcriptome analyses suggest that CSN1 has a more prominent role than CSN5A during seed maturation, but CSN5A plays a more important role than CSN1 during seed germination, further supporting the functional distinction of these two CSN genes. Our study delineates the molecular targets of the CSN complex in seed germination, and reveals that CSN5 has additional functions in regulating ABI5, thus the ABA signaling pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.