ReviewAnesthesiology2018
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Review in Anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 942 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cerebrospinal Fluid and Serum Inflammatory Biomarkers in Predicting Perinatal Depression and Persistent Pain After Cesarean Delivery
Evaluation of the Relationship Between Craniovertebral Angle and Fibromyalgia Symptom Severity
From Mechanisms to Clinical Evidence: A Cross-Sectional Study of Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain
Who cites it
942 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,454 citations in OpenAlex.
- Role of Supraspinal Neuroinflammation in Chronic Pain After Experimental Spinal Cord Injury-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Musculoskeletal pain in adolescents: a systematic review of predictive and associated factors.BMC pediatrics · 2026Pooled it
- Fascia iliaca compartment block for postoperative hip fracture pain: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Risk of cancer incidence and mortality in patients with chronic pain: A systematic review and meta-analysis.Cancer metastasis reviews · 2026Pooled it
- Chronic pain and risk of cognitive impairment: a meta-analysis of longitudinal cohort studies.Translational psychiatry · 2026Pooled it
- Sexually Dimorphic Neuroimmune Pathways in Chronic Pain: A Comprehensive Systematic Review of Cellular and Molecular Mechanisms.Biomolecules · 2026Pooled it
- The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes.Pain research & management · 2026Pooled it
- Comparative effectiveness of non-pharmacological interventions for depression and anxiety in chronic low back pain: a Bayesian network meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Mapping neuroimaging research related to post-traumatic headache after traumatic brain injury: a multi-database bibliometric analysis.Frontiers in neuroscience · 2026Pooled it
- Factors predicting health-enhancing physical activity in patients with chronic widespread pain following a person-centred health plan.Annals of medicine · 2026Trial
- Application of SPI-guided analgesia in laparoscopic gynecologic surgery: a randomized controlled trial evaluating the remifentanil-sparing effect and predictive value of time-weighted SPI.Journal of clinical monitoring and computing · 2026Trial
- Clinical effects of passive cable theory applied via subthreshold electrical stimulation in chronic neck pain: A randomized trial.PM & R : the journal of injury, function, and rehabilitation · 2026Trial
- Liposomal bupivacaine in thoracic paravertebral nerve block for postoperative analgesia following video-assisted thoracoscopic lobectomy: a prospective, double-blind, randomized controlled trial.BMC anesthesiology · 2026Trial
- Dexmedetomidine-Ketamine-Based Multimodal General Anesthesia with Electroencephalographic Spectrogram-Guided Titration Improves Early Recovery After Lumbar Spine Fusion in Older Adults: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Sleep disturbance in patients undergoing shoulder surgery: a current concepts review.JSES reviews, reports, and techniques · 2026Review
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats.Neurochemical research · 2026Article
- Effects of aquatic exercise on nociceptive behavior, systemic inflammation, and skeletal muscle redox status in healthy and reserpine-treated rats.Journal of bioenergetics and biomembranes · 2026Article
- Preliminary evidence of neuroimmune system disruption in opioid use disorder: Findings from a pilot PET TSPO imaging study.Brain, behavior, & immunity - health · 2026Article
- Altered somatosensory temporal discrimination in chronic non-specific low back pain patients with central sensitization-related features: a cross-sectional study.The Korean journal of pain · 2026Article
882 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system. A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines. Recent studies suggest that central cytokines and chemokines are powerful neuromodulators and play a sufficient role in inducing hyperalgesia and allodynia after central nervous system administration. Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affects multiple body sites. Thus, neuroinflammation drives widespread chronic pain via central sensitization. We also discuss sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.