ArticleInternational forum of allergy & rhinology2018
Clinical associations between allergies and rapid eye movement sleep disturbances.
Article in International forum of allergy & rhinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Sleep and chronic rhinosinusitis: a systematic review of postoperative data.Sleep science (Sao Paulo, Brazil) · 2025Review
- Rapid eye movement dependency is associated with increased inflammatory activity in obstructive sleep apnea syndrome.Brain and behavior · 2024Article
- Effect of house dust mite allergen on sleep parameters and sleep quality.Sleep & breathing = Schlaf & Atmung · 2023Article
- Recognizing Poor Sleep Quality Factors During Oral Health Evaluations.Clinical medicine & research · 2019Review
- Clinical associations between allergies and rapid eye movement sleep disturbances.International forum of allergy & rhinology · 2018Article
- Severity of allergic rhinitis impacts sleep and anxiety: results from a large Spanish cohort.Clinical and translational allergy · 2018Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion-respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status.
methodsA retrospective analysis of 100 patients compared REM-RDI results in 67 allergen-positive patients with 33 nonallergic patients who presented with nasal blockage. Subjects completed STOP-Bang©, 22-item Sino-Nasal Outcome Test (SNOT-22)©, and Epworth Sleepiness Scale© questionnaires and underwent skin-prick testing (SPT) and PSGs including REM-RDI values. Using multivariate logistic regression models, we evaluated relationships between allergic status and sleep parameters while controlling for possible confounders including body mass index (BMI).
resultsUsing REM-RDI as the outcome of interest, allergen-positive patients were 3.92 times more likely to have REM-RDI values in a moderate/severe range (≥15 events/hour); and patients with moderate/severe REM-RDI values were more likely to be allergen positive (p < 0.05). Allergic status was not significantly related to all-night AHI, RDI, or REM-AHI. BMI was not significantly related to REM-RDI. STOP-Bang© was related to allergy status (p = 0.02) and REM-RDI (p < 0.01). Allergic patients had increased REM latency and less total amount of REM.
conclusionWe revealed significant bidirectional associations between allergen positivity and increased REM-RDI values independent of BMI, AHI, RDI, and REM-AHI. Allergic inflammation and REM-RDI data may play important roles in diagnosing and treating fatigued SDB patients and as objective perioperative safety and outcomes measures.
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