ArticleThe New phytologist2018
Mutational studies of the Aux/IAA proteins in Physcomitrella reveal novel insights into their function.
Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants.Nature plants · 2025Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
- Genetically Encoded, Noise-Tolerant, Auxin Biosensors in Yeast.ACS synthetic biology · 2024Article
- Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution.Plant communications · 2024Article
- Dissection of transcriptional events in graft incompatible reactions of "Bearss" lemon (Frontiers in plant science · 2024Article
- PpARF6 acts as an integrator of auxin and ethylene signaling to promote fruit ripening in peach.Horticulture research · 2023Article
- Genome-wide identification and expression analysis of the AUX/IAA gene family in turnip (Brassica rapa ssp. rapa).BMC plant biology · 2023Article
- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress.BMC plant biology · 2022Article
- Article
- Expression Analysis of AUX/IAA Family Genes in Apple Under Salt Stress.Biochemical genetics · 2022Article
- Auxin/Cytokinin Antagonistic Control of the Shoot/Root Growth Ratio and Its Relevance for Adaptation to Drought and Nutrient Deficiency Stresses.International journal of molecular sciences · 2022Review
- Phytohormone biosynthesis and signaling pathways of mosses.Plant molecular biology · 2021Review
- Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021Review
- Expansion and innovation in auxin signaling: where do we grow from here?Development (Cambridge, England) · 2021Review
- Auxin Biology in Bryophyta: A Simple Platform with Versatile Functions.Cold Spring Harbor perspectives in biology · 2021Review
- Genetic dissection of the auxin response network.Nature plants · 2020Review
- Regulation of auxin transcriptional responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- New different origins and evolutionary processes of AP2/EREBP transcription factors in Taxus chinensis.BMC plant biology · 2019Article
- The roles of Aux/IAA gene family in development of Dendrocalamus sinicus (Poaceae: Bambusoideae) inferred by comprehensive analysis and expression profiling.Molecular biology reports · 2019Article
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Abstract
The plant hormone auxin regulates many aspects of plant growth and development. Auxin signaling involves hormone perception by the TRANSPORT INHIBITOR RESPONSE/AUXIN F-BOX (TIR1/AFB)-Aux/IAA co-receptor system, and the subsequent degradation of the Aux/IAA transcriptional repressors by the ubiquitin proteasome pathway. This leads to the activation of downstream gene expression and diverse physiological responses. Here, we investigate how the structural elements in the Aux/IAAs determine their function in Auxin perception and transcriptional repression. We took advantage of the facile genetics of the moss Physcomitrella patens to determine the activity of wild-type and mutant PpIAA1a proteins in a Δaux/iaa null background. In this way, Aux/IAA function was characterized at the molecular and physiological levels without the interference of genetic redundancy. We identified and characterized degron variants in Aux/IAAs that affect their stability and Auxin response. We also demonstrated that neither the Aux/IAA EAR motif nor Aux/IAA oligomerization is essential for the repressive function of Aux/IAA. Our study demonstrates how key elements within the Aux/IAA proteins fine tune stability and repressor activity, as well as the long-term developmental outcome.
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