ArticleNature chemistry2018
Palladium-catalysed anti-Markovnikov selective oxidative amination.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Palladium-catalyzed asymmetric migratory diarylation of unactivated directing-group-free internal alkenes.Nature communications · 2026Article
- Pd- and Cu-Cocatalyzed Anaerobic Olefin Aminoboration.The Journal of organic chemistry · 2025Article
- Indirect Anti-Markovnikov Hydrofunctionalization of Terminal Alkenes via an Alkenyl Thianthrenium Intermediate.Angewandte Chemie (International ed. in English) · 2025Article
- Direct synthesis of branched amines enabled by dual-catalyzed allylic C─H amination of alkenes with amines.Science advances · 2024Article
- Nitrene transfer from a sterically confined copper nitrenoid dipyrrin complex.Chemical science · 2023Article
- Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration.Journal of the American Chemical Society · 2023Article
- Multi-site programmable functionalization of alkenes via controllable alkene isomerization.Nature chemistry · 2023Article
- Mechanical Activation of Zero-Valent Metal Reductants for Nickel-Catalyzed Cross-Electrophile Coupling.ACS catalysis · 2022Article
- Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines.Nature chemistry · 2022Article
- Palladium-Catalyzed Oxidative Amination of α-Olefins with Indoles.Organic letters · 2022Article
- Construction of sulfur-containingRSC advances · 2022Article
- γ-Selective C(spNature communications · 2021Article
- Copper-Mediated Radical-Polar Crossover Enables Photocatalytic Oxidative Functionalization of Sterically Bulky Alkenes.Journal of the American Chemical Society · 2021Article
- Intermolecular oxidative amination of unactivated alkenes by dual photoredox and copper catalysis.Chemical science · 2020Article
- Allylic Amination of Alkenes with Iminothianthrenes to Afford Alkyl Allylamines.Journal of the American Chemical Society · 2020Article
- Ru-catalyzed isomerization of ω-alkenylboronates towards stereoselective synthesis of vinylboronates with subsequentChemical science · 2020Article
- Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.Chemical science · 2019Article
- Energy Decomposition Analyses Reveal the Origins of Catalyst and Nucleophile Effects on Regioselectivity in Nucleopalladation of Alkenes.Journal of the American Chemical Society · 2019Article
- Nickel-catalysed selective migratory hydrothiolation of alkenes and alkynes with thiols.Nature communications · 2019Article
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5 authors.
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Abstract
In recent years, the synthesis of amines and other nitrogen-containing motifs has been a major area of research in organic chemistry because they are widely represented in biologically active molecules. Current strategies rely on a multistep approach and require one reactant to be activated prior to the carbon-nitrogen bond formation. This leads to a reaction inefficiency and functional group intolerance. As such, a general approach to the synthesis of nitrogen-containing compounds from readily available and benign starting materials is highly desirable. Here we present a palladium-catalysed oxidative amination reaction in which the addition of the nitrogen occurs at the less-substituted carbon of a double bond, in what is known as anti-Markovnikov selectivity. Alkenes are shown to react with imides in the presence of a palladate catalyst to generate the terminal imide through trans-aminopalladation. Subsequently, olefin isomerization occurs to afford the thermodynamically favoured products. Both the scope of the transformation and mechanistic investigations are reported.
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