SynthesisNutrients2018
Donor Human Milk Protects against Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- A systematic review of economic evaluations for donor human milk versus standard feeding in infants.Maternal & child nutrition · 2021Pooled it
- Mother's Own Milk and Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2019Pooled it
- A Systematic Review and Meta-Analysis of Human Milk Feeding and Morbidity in Very Low Birth Weight Infants.Nutrients · 2018Pooled it
- Effect of an Exclusive Human Milk Diet on the Gut Microbiome in Preterm Infants: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Cardiovascular development of critically ill neonates on mother's milk.Pediatric research · 2026Article
- Effects of preterm birth and gestational diabetes on innate lymphoid cells (ILCs) in human breast milk.Molecular and cellular pediatrics · 2026Article
- Improving resilience in human milk banking: workshop proceedings, 11th November, London UK.BMC proceedings · 2026Article
- Short outcomes of donor milk and mother's own milk for preterm infants.Pediatric research · 2026Article
- Exploring human milk donation: A cross-sectional study.Public health in practice (Oxford, England) · 2026Article
- Beyond bronchopulmonary dysplasia: impact of human milk feeding on long-term respiratory morbidity in very preterm infants.European journal of pediatrics · 2026Article
- Article
- Risk factors for BPD and relevant nursing models of care to improve outcomes: a narrative review.Frontiers in pediatrics · 2026Review
- Preterm birth, airway microbiome, and the evolutionary origins of asthma.Evolution, medicine, and public health · 2026Article
- Human OPN-derived peptide SV prevents BPD model through interacting with KIF5B to repair mitochondrial damage and inhibit apoptosis.iScience · 2025Article
- Analysis of the economic benefits and feasibility of the same-city delivery model for donor human milk (SCDM-DHM).International breastfeeding journal · 2025Article
- Review
- Microbiological Safety of Donor Human Milk: Comparing Culture-Based Methods for Enterobacterales Detection.Microorganisms · 2025Article
- Impact of donor human milk pasteurization methods on the gut microbiome of preterm infants.Pediatric research · 2025Article
- Perinatal Antibiotic Exposure and Respiratory Outcomes in Children Born Preterm.JAMA network open · 2025Article
- Human milk bank services and Islamic milk kinship: pathways and processes for ensuring respect for religious law and tradition in the provision of donor human milk for small vulnerable newborns.International breastfeeding journal · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bronchopulmonary dysplasia (BPD) is the most common complication after preterm birth. Pasteurized donor human milk (DHM) has increasingly become the standard of care for very preterm infants over the use of preterm formula (PF) if the mother's own milk (MOM) is unavailable. Studies have reported beneficial effects of DHM on BPD. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies on the effects of DHM on BPD and other respiratory outcomes. Eighteen studies met the inclusion criteria. Meta-analysis of RCTs could not demonstrate that supplementation of MOM with DHM reduced BPD when compared to PF (three studies, risk ratio (RR) 0.89, 95% confidence interval (CI) 0.60-1.32). However, meta-analysis of observational studies showed that DHM supplementation reduced BPD (8 studies, RR 0.78, 95% CI 0.67-0.90). An exclusive human milk diet reduced the risk of BPD, compared to a diet with PF and/or bovine milk-based fortifier (three studies, RR 0.80, 95% CI 0.68-0.95). Feeding raw MOM, compared to feeding pasteurized MOM, protected against BPD (two studies, RR 0.77, 95% CI 0.62-0.96). In conclusion, our data suggest that DHM protects against BPD in very preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.