Evidence map›Paper›PMID 29461204›Full record

ArticleeLife2018

SAC1 degrades its lipid substrate PtdIns4

James P Zewe, Rachel C Wills, Sahana Sangappa, Brady D Goulden, Gerald Rv Hammond

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
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  8. bioRxiv : the preprint server for biology · 2026
    Article
  9. Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

James P ZeweDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID http://orcid.org/0000-0001-5086-9052
Rachel C WillsDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID http://orcid.org/0000-0003-2161-9235
Sahana SangappaDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Brady D GouldenDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID http://orcid.org/0000-0002-1954-2091
Gerald Rv HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID http://orcid.org/0000-0002-6660-3272
University of Pittsburgh · US

Funding

Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
NIGMS NIH HHS 1R35GM119412-01NIGMS NIH HHS R35 GM119412
6 · The paper itself

Abstract

Gradients of PtdIns4

Indexed as

AnimalsChlorocebus aethiopsCOS CellsEndoplasmic ReticulumHEK293 CellsHumansPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesSaccharomyces cerevisiae Proteinsphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesSAC1 protein, S cerevisiaeSaccharomyces cerevisiae Proteinscell biologyhumanmembrane junctionsPhosphatidylinositolsPI4PPIP2

Identifiers

PMID29461204
PMCPMC5829913
OpenAlexW2788736668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.