Evidence map›Paper›PMID 29461171›Full record

ArticleDrug delivery2018

New model of proliferative vitreoretinopathy in rabbit for drug delivery and pharmacodynamic studies.

Sang Woong Moon, Yaoyao Sun, David Warther, Kristyn Huffman, William R Freeman, Michael J Sailor, Lingyun Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sang Woong Moona Department of Ophthalmology , Jacobs Retina Center at Shiley Eye Institute, University of California San Diego , La Jolla , CA , USA.
Yaoyao Suna Department of Ophthalmology , Jacobs Retina Center at Shiley Eye Institute, University of California San Diego , La Jolla , CA , USA.
David Wartherd Department of Chemistry and Biochemistry , University of California San Diego , La Jolla , CA , USA.
Kristyn Huffmana Department of Ophthalmology , Jacobs Retina Center at Shiley Eye Institute, University of California San Diego , La Jolla , CA , USA.ORCID http://orcid.org/0000-0002-3271-2518
William R Freemana Department of Ophthalmology , Jacobs Retina Center at Shiley Eye Institute, University of California San Diego , La Jolla , CA , USA.
Michael J Sailord Department of Chemistry and Biochemistry , University of California San Diego , La Jolla , CA , USA.
Lingyun Chenga Department of Ophthalmology , Jacobs Retina Center at Shiley Eye Institute, University of California San Diego , La Jolla , CA , USA.ORCID http://orcid.org/0000-0002-0748-5173
University of California San Diego · USKyung Hee University · KRPeking University · CN

Funding

Porous Silicon Particles for Sustained Intravitreal Drug DeliveryR01EY020617 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHENG, LINGYUN · 2011 to 2015
$2.6M
NEI NIH HHS R01 EY020617
6 · The paper itself

Abstract

Blinding retinal diseases become more epidemic as the population ages. These diseases, such as diabetic retinopathy and macular edema, are of chronic nature and require protracted drug presence at the disease site. A sustained intravitreal porous silicon delivery system with dexamethasone (pSiO

Indexed as

AnimalsCollagenDelayed-Action PreparationsDexamethasoneDrug CombinationsDrug Delivery SystemsFluorescein AngiographyIntravitreal InjectionsLamininNeovascularization, PathologicProteoglycansRabbitsTomography, Optical CoherenceVascular Endothelial Growth Factor AVitreoretinopathy, ProliferativeVitreous BodyCollagenDelayed-Action PreparationsDexamethasoneDrug CombinationsLamininmatrigelProteoglycansVascular Endothelial Growth Factor Adexamethasonefundus fluorescein angiographyIntravitreal drug deliveryMatrigelOCTporous siliconrabbit model of PVRsubretinal injectionVEGF

Identifiers

PMID29461171
PMCPMC6058613
OpenAlexW2790027626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.